Study of neuronal plasticity in children by biomagnetism

生物磁学研究儿童神经元可塑性

• 批准号: 11670735
• 负责人: IINUMA Kazuie
• 金额: $ 2.56万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670735/
• 关键词: neuronal plasticity; cortical dysplasia; MEG; SEF; detection of epileptic activity; 大脳半球巨大嚢胞; bandheterotopia

Neuronal plasticity is that the damage to the neuron will recover and/or a cirtain brain region will contain other function. The plasticity will occur more dramatically in immature brain. The purpose of this project is to determine the function of injured brain in childhood and whether some area of the brain other than original region possess functioning. We evaluated the distribution of the brain function in cortical dysplasias using magnetoencephalography (MEG).The subjects included 2 cases of focal cortical dysplasia, 2 cases of band heterotopia, each one case of hemimegalencephaly and periventricular nodular heterotopia, 2 cases of hemispheric cortical dysplasia, and other 3 cases of cartical displasia, Sensory evoked fields (SEF) induced by left and right median nerve stimulation were recorded in a magnetically shielded room using a 122-channel whole head MEG system (Neuromag-122, Neuromag Ltd.)The central sulci were identified according to the signal sourse of SEF in 6 out of the 11 cases cortical dysplasia and abnormal patterm of gyri around the central sulcus.In the 4 cases, the latency, amplitude and direction of the electric current of N20m showed abnormal. The abnormal direction of the electric current implies that the fomation of neurons were distorted during neuronal migration period. In cases of migration disorders, the electrophysiological parameters show variable changes. This heterogeueity is likely due to distortion of neuronal arrangement during migrating period.Signal sourse analysis of epileptic activity in cases of hemispheric cortical dysplasia with abnormal pattern of gyri and sulci decreased volume in the affected side. Epileptic activity was found in the affected hemisphere in 2 cases. In one case, another epileptic activity was also observed in the non-affected hemisphere in which EEG could not detected epileptic discharges. The MEG has superiority for detection of scarce epileptic activity.

神经元可塑性是指神经元的损伤将会恢复和/或某个大脑区域将包含其他功能。在未成熟的大脑中，可塑性会更加显着。该项目的目的是确定儿童时期受损大脑的功能以及除原始区域之外的大脑某些区域是否具有功能。采用脑磁图（MEG）评估皮质发育不良患者的脑功能分布情况。研究对象包括局灶性皮质发育不良2例、带状异位2例、半侧巨脑畸形和脑室周围结节性异位各1例、半球皮质发育不良2例、其他3例软骨发育不全。 采用122通道全头脑磁图系统（Neuromag-122，Neuromag Ltd.）在磁屏蔽室内记录左右正中神经刺激诱发的场（SEF）。11例皮质发育不良和中央沟周围回回异常模式的病例中，有6例根据SEF信号源识别中央沟。 N20m的电流潜伏期、幅度和方向均显示异常。电流方向的异常表明神经元迁移过程中神经元的形态发生了扭曲。在迁移障碍的情况下，电生理参数显示出可变的变化。这种异质性可能是由于迁移期间神经元排列的扭曲造成的。对半球皮质发育不良伴脑回和脑沟异常模式、患侧体积减少的癫痫活动进行信号源分析。 2例患侧半球出现癫痫活动。在一个病例中，在未受影响的半球中也观察到另一种癫痫活动，其中脑电图无法检测到癫痫放电。 MEG 在检测稀有癫痫活动方面具有优势。

项目成果

Ishitobi M.,Nakasato N.,Inoue T.,Ohnuma A.,Kanno A.,Iinuma K.,Yoshimoto T.: "Residual Function Detected by MEG and Functional MRI in Abnormally Thin Cortex Caused by a Large Congenital Brain Cyst"Recent Advances in Biomagnetism (Tohoku University Press, S

Ishitobi M.、Nakasato N.、Inoue T.、Ohnuma A.、Kanno A.、Iinuma K.、Yoshimoto T.：“通过 MEG 和功能 MRI 检测大型先天性脑囊肿引起的异常薄皮质中的残余功能”最近

Ishitobi M, Nakasato N, Inoue T, Ohnuma A, Kanno A, Iinuma K, Yoshimoto T: "Residual Function Detected by MEG and Functional MRI in Abnormally Thin Cortex Caused by a Large Congenital Brain Cyst, Recent Advances in Biomagnetism"Tohoku University Press, Se

Ishitobi M、Nakasato N、Inoue T、Ohnuma A、Kanno A、Iinuma K、Yoshimoto T：“通过 MEG 和功能 MRI 检测大型先天性脑囊肿引起的异常薄皮层的残余功能，生物磁学的最新进展”东北大学出版社

Ishitobi M,Nakasato N,Inoue T,Ohnuma A,Kanno A,Iinuma K,Yoshimoto T: "Recent Advances in Biomagnetism (Tohoku University Press, Sendai)"Residual Function Detected by MEG and Functional MRI in Abnormally Thin Cortex Caused by a Large Congenital Brain Cyst.

Ishitobi M、Nakasato N、Inoue T、Ohnuma A、Kanno A、Iinuma K、Yoshimoto T：“生物磁学的最新进展（东北大学出版社，仙台）”通过 MEG 和功能 MRI 检测大面积异常薄皮层中的残余功能

Ishitobi M,Nakasato N,Inoue T,Ohnuma A,Kanno A,Iinuma K.Yoshimoto T: "Recent Advances in Biomagnetism (Tohoku University Press, Sendai)"Residual Function Detected by MEG and Functional MRI in Abnormally Thin Cortex Caused by a Lanrge Congenital Brain Cyst

Ishitobi M、Nakasato N、Inoue T、Ohnuma A、Kanno A、Iinuma K.Yoshimoto T：“生物磁学的最新进展（东北大学出版社，仙台）”通过 MEG 和功能 MRI 检测由 LANRGE 引起的异常薄皮质中的残余功能