权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

ESTABLISHMENT OF A NOVEL THERAPY INCLUDING MILD HYPOTHERMIA AGAINST ACUTE ENCEPHALOPATHY IN CHILDREN

建立一种包括轻度低温在内的针对儿童急性脑病的新疗法

基本信息

批准号：
11670774
负责人：
AIHARA Yukoh
金额：
$ 2.24万
依托单位：
YOKOHAMA CITY UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670774/
关键词：
ACUTE ENCEPHALOPATHY IN CHILDREN THERAPY HYPOTHERMIA 小児

项目摘要

ACUTE ENCEPHALOPATHY IS ONE OF SEVERE DISORDERS IN CHILDHOOD.ALTHOUGH, IT'S PATHOPHYSIOLOGY REMAINS UNKNOWN, IT IS NOW KNOWN THAT ONE OF RELATED FACTORS IS INFLUENZA VIRUS INFECTION.THE INFLUENZA INFECTION MIGHT INDUCE THE FAILURE OF BLOOD-BRAIN BARRIER AND THE ABNORMAL PRODUCTION OF SEVERAL CYTOKINES, FOLLOWED BY THE MASSIVE DEATH OF NEURONS.THEREFORE, THE STRATEGY TO TREAT THE DISEASE IS TO PREVENT THE CASCADE OF THE EVENTS.IN ADDITION, WE REPORTED THAT THERE WAS A LIMITED EFFICACY IN THE DISEASE WITH THE CONVENTIONAL THERAPIES.THEREFORE, WE TRY TO ESTABLISH A NOVEL THERAPY INCLUDING MILD HYPOTHERMIA AND METHYLPREDNISOLONE PULSE THERAPY TO IMPROVE THE OUTCOME OF THE PATIENTS WITH THE DISEASE.BEFORE STARTING THE NEW THERAPY, WE ANALYZED THE PRECISE DATA OF 35 PATIENTS WITH ACUTE ENCEPHALOPATHY UNDER THE CONVENTIONAL THERAPY.THE OUTCOME WAS BAD.THAT IS, 10 PATIENTS WERE DEAD.ONE THIRD HAD SEVERE DISABILITY IN DAILY LIFE.ONE THIRD HAD MILD DISABILITIES.WE ESTABLISHED A NOVEL THERAPY INCLUDING MILD HYPOTHERMIA AND METHYLPREDNISOLONE COMBINATION AGAINST ACUTE ENCEPHALOPATHY AND/OR ENCEPHALITIS.SO FAR WE APPLIED THIS THERAPY TO 10 PATIENTS.IT SEEMS THAT THE OUTCOMES OF THE PATIENTS WITH THIS THERAPY BECOME BETTER THAN THOSE WITH CONVENTIONAL THERAPY.IT IS TOO EARLY TO CONCLUDE THE EFFICACY OF THIS NEW THERAPY.HOWEVER, WE BELIEVE THAT THIS NOVEL THERAPY IS PROMISING.NOW, TO ESTABLISH THE THERAPY WE HAVE TO DETERMINE A CRITERIA OF THE PATIENTS TO APPLY THE THERAPY AS WELL AS TO INCREASE THE NUMBER OF THE PATIENTS WITH THE THERAPY.

急性脑病是儿童时期的严重疾病之一。尽管其病理生理学尚不清楚，但现已知道相关因素之一是流感病毒感染。流感病毒感染可能导致血脑屏障失效和多种细胞因子的异常产生，随后导致神经元大量死亡。因此，治疗该疾病的策略是防止事件的连锁反应。此外，本文报道了急性脑病常规治疗效果有限，为此，我们尝试建立一种新的治疗方法，包括轻度低温和甲基强的松龙脉冲疗法，以改善患者的预后。在开始新的治疗方法之前，我们对35例急性脑病患者的资料进行了分析，结果表明，常规治疗效果不佳，即，10例死亡，1/3重度生活障碍，1/3轻度生活障碍。我们建立了一种新的治疗方法，包括轻度低温和甲基强的松龙联合治疗急性脑病和/或到目前为止，我们对10名病人进行了这种治疗，病人的结果似乎比常规治疗的病人好，现在下结论还为时过早这种新疗法的有效性。然而，我们相信这种新疗法是有希望的。现在，为了建立这种疗法，我们必须确定一个标准的患者，以应用这种疗法，以及增加接受这种疗法的患者人数。