ESTABLISHMENT OF "THEUMATIC CHRONIC FATIGUE SYNDROME IN CHILDREN" AND NATIONWIDE SURVEY OF ITS FREQUENCY

“儿童慢性疲劳综合症风湿病”的建立及全国发病率的调查

• 批准号: 07670885
• 负责人: AIHARA Yukoh
• 金额: $ 1.47万
• 依托单位: YOKOHAMA CITY UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670885/
• 关键词: RHEUMATIC CHRONIC FATIGUE SYNDROME IN CHILDREN; ANTINUCLEAR ANTIBODY; DEFINITION

WE ANALYZED 23 PATIENTS WITH "RHEUMATIC CHRONIC FATIGUE SYNDROME IN CHILDHOOD". FEMALE IS PREDOMINANT (91%), AND THERE WERE NO SPECIFIC CLINICAL SYMPTOMS. HOWEVER, FEVER (61%), ARTHRALGIA (57%), GENERAL FATIGUE (48%) AND HEADACHE (35%) WERE FREQUENTLY OBSERVED. AS FOR LABORATORY DATA, ALL PATIENTS HAVE ANTlNUCLEAR ANTIBODY(ANA) WITH LOW TITER (1:40-1:640) IN SERA. THE FLUORESCENT PATTERN OF ANAS IN ALL BUT ONE (96%) WERE HOMOGENEOUS/SPECKLED. IN SOME PATIENTS, RHEUMATOID FACTOR, HYPERGAMMAGLOBULINEMIA AND ACCELERATION OF ESR WERE OBSERVED. OTHER AUTOIMMUNE ANTIBODIES WERE NOT DETECTED IN MOST PATIENTS. THE LEVELS OF SERUM COMPLEMENT, ELECTROENCEPHALOGRAM AND PSYCHOLOGICAL ANALYSIS WERE NORMAL.FAMILY STUDY REVEALED THAT 55% OF THEIR MOTHERS HAD SIMILARLY LOW TITER (1:40-1:80) OF ANA IN SERA. THE FLUORESCENT PATTERNS OF ANAS WERE ALL HOMOGENEOUS/SPECKLED. SOME OF THEM HAD THE SAME SYMPTOMS OF THE PATIENT.FROM THE ANALYSIS OF ANTIGENS RECOGNIZED BY ANAS IN PATIENTS, SO FAR WE COULD NOT DETECT ANY SPECIFIC BANDS COMMONLY SEEN IN THE PATIENTS WITH IMMUNOBLOTTlNG.WE HAVE FINISHED THE ANALYSIS OF CLINICAL SYMPTOMS AND LABORATORY DATA COMMONLY USED IN CLINIC IN THE PATIENTS. HOWEVER, WE STILL HAVE BEEN TRYING TO FIND OUT SPECIFIC MAKERS IN ANA AND TO ESTABLISH NEW DEFINITIONS OF THIS SYNDROME. IN PRELIMINARY STUDY, THERE WERE NOT A FEW PATIENTS FITTED WITH THE SYMPTOMS AND LABORATORY DATA MENTIONED ABOVE.IN NEAR FUTURE WE WILL DO A NATION-WIDE SURVEY OF THIS SYNDROME WITH THE NEWLY ESTABLISHED DEFINITION.

本文对23例儿童风湿性慢性疲劳综合征进行了分析。女性占绝大多数（91%），无特异性临床症状。然而，经常观察到发热（61%）、关节痛（57%）、全身疲乏（48%）和头痛（35%）。实验室检查全部病人血清抗核抗体（ANA）均为低滴度（1：40-1：640）。除1例（96%）外，所有患者的Anas荧光模式均为均匀/斑点状。部分患者出现凝血因子、高丙种球蛋白血症和血沉增快。其他自身免疫抗体在大多数患者中未检出。血清补体、脑电图及心理分析均正常，家系调查发现55%的母亲血清抗核抗体（ANA）滴度均为低滴度（1：40-1：80）。阿纳斯的荧光模式均为均匀/斑点状。通过对病人的ANA识别抗原分析，目前未发现免疫印迹病人常见的特异性条带，完成了对病人临床症状和实验室资料的分析。然而，我们仍在试图找出ANA的具体制造者，并建立这种综合征的新定义。在初步研究中，符合上述症状和实验室资料的患者不在少数，我们将在不久的将来对这一新定义进行全国性的调查。

项目成果

Y.Aihara,C.Shimizu,Y.Fujiwara,S.Yokota: "Acute anterior in a child with HLA-B60 after salmonella enteritis associated with transient appearance of auto-antibody"Acta Paediatrica Japonica. 38. 286-287 (1996)

Y.Aihara、C.Shimizu、Y.Fujiwara、S.Yokota：“沙门氏菌肠炎与自身抗体短暂出现相关的 HLA-B60 儿童急性前壁”Acta Paediatrica Japonica。

Y.AIHARA: "ANTINUCLEAR ANTIBODY"JPM. (IN PRESS).

Y.AIHARA：“抗核抗体”JPM。

S.Yokota,T.Imagawa,S.Katakura,S.itoh,T.Mitsuda,S.Fujikawa,Y.Aihara: "Mixed connective tissue disease in childhood : A nationwide retrospective study in Japan"Acta Paediatrica Japonica. 39. 273-276 (1997)

S.Yokota，T.Imakawa，S.Katakura，S.itoh，T.Mitsuda，S.Fujikawa，Y.Aihara：“儿童期混合结缔组织病：日本全国性回顾性研究”Acta Paediatrica Japonica。

S.Yokota, T.Imagawa, S.Katakura, S.Itoh, T.Mitsuda, S.Fujikawa, Y.Aihara: "Mixed connective tissue disease in childhood: A nationwide retrospective study in Japan"Acta Paediatrica Japonica. 39. 273-276 (1997)

S.Yokota、T.Imakawa、S.Katakura、S.Itoh、T.Mitsuda、S.Fujikawa、Y.Aihara：“儿童期混合结缔组织病：日本全国性回顾性研究”Acta Paediatrica Japonica。

相原雄幸、森雅亮、友野順章、今川智之、片倉茂樹、高橋由利子、満田年宏、横田俊平: "感染症罹患に伴い抗核抗体が検出された5症例の臨床的検討"小児感染免疫. 9. 115-120 (1997)

Yuyuki Aihara、Masaaki Mori、Junaki Tomono、Tomoyuki Imakawa、Shigeki Katakura、Yuriko Takahashi、Toshihiro Mitsuda、Shunpei Yokota：“因感染而检测到抗核抗体的五例临床回顾”小儿感染免疫学 9. 115-120（ 1997）