EPICEMIOLOGICAL STUDY AND ESTABLISHMENT OF FOOD-DEPENDENT EXERCISE-INDUCED ANAPHYLAXIS

食物依赖型运动诱发过敏反应的流行病学研究和建立

• 批准号: 13670824
• 负责人: AIHARA Yukoh
• 金额: $ 1.86万
• 依托单位: YOKOHAMA CTY UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670824/
• 关键词: FOOD-DEPENDENT EXERCISE-INDUCED ANAPHYLAXIS; EPIDEMIOLOGY (3) PROVOCATION TEST; 病態解析

FOOD-DEPENDENT EXERCISE-INCUCED ANAPHYLAXIS (FEIAN) IS CALASSIFIED AMONG PHYSICAL ALLERGY. HOWEVER, THE PATHOPHYSIOLOGY OF FEIAN REMAINS UNKNOWN AS DOES THE EPIDEMIOLOGY OF FEIAN IN THE GENERAL. THEREFORE, WE STUDIED THE EPIDEMIOLOGY OF FEIAN, ESPESICALLY ITS FREQUENCY IN JUNIOR HIGH SCHOOL AND HIGH SCHOOL STUDENTS IN JAPAN.A QUESTIONNAIRE ASKING ABOUT THE OCCURRENCE OF FEIAN IN THESE POPULATIONS WAS SENT TO ALL 145 PUBLIC JUNIOR HIGH SCHOOL NURSES IN YOKOHAMA AND 166PUBLIC HIGH SCHOOL NURSES IN KANAGAWA PREFECTURE, JAPAN.130 JUNIOR HIGH SCHOOL NURSES AND138 SCHOOL NURSES RESPONDED THE QUESTIONNAIRE, AND 13 CASES OF FEIAN (11 BOYS, 2 GIRLS) IN 76, 229 JUNIOR HIGH SCHOOL STUDENTS AND 9 CASES (6 BOYS, 3 GIRLS) IN 104,701 HIGH STUDENTS WERE REPORTED. IN ADDITION, 24 CASES OF EXERCISE-INDUCED ANAPHYLAXIS (EIAN) (12 BOYS, 12 GIRLS) IN JUNIOR HIGH SCHOOL AND 17 (9 BOYS, 8 GIRLS) WERE DETECTED.FROM THIS SURVEY, THE FREQUENCY OF FEIAN AND EIAN WAS 0.017% AND 0.034% IN JUNIOR HIGH SCHOOL AND 0.086% AND 0.016% IN HIGH SCHOOL, RESPECTIVERLY. ONLY ONE HALF OF SCHOOL NURSES HAD ANY KNOWLEDGE OF FEOAN. WE ALSO PERFORMED PROVOCATION TESTS IN 9 OF THE 22 STUDENTS WITH FEIAN AFTER OBTAINING THERIR INFORMED CONSENTS AND CONFIRMED THE DIAGNOSIS.ESTABLISHMENT OF ANIMAL MODEL OF FEIAN IS STILL ON THE WAY TO DEVELOP. NOW, WE FOUND ONE CANDIDATE OF THE ANIMAL MODEL. IT STILL KAKES A TIME TO GET THE FINAL RESULTS.THIS STUDY SHOWED THAT FEIAN AND EIAN ARE RELATIVEL Y RARE IN JUNIOR HIGH SCHOOL AND HIGH SCHOOL STUDENTS IN JAPAN. TO ACOID SERIOUS OUTCOMES AND UNNECESSARY RESTRICTIONS, IT IS IMPORTANT FOR PHYSICANS, BUT ALSO SCHOOL NURSES AND TEACHERS OF PHYSICAL EDUCATION TO BE FAMILIAR WITH THE DISEASES.

食物依赖性运动诱发的过敏性反应（FEIAN）被归类为物理过敏。然而，肺安的病理生理学仍然是未知的，就像肺安的流行病学一样。因此，我们研究了日本初中和高中学生的飞安流行病学，特别是其发生率。向日本横滨市所有145名公立初中学生和神奈川县166名公立高中学生发送了一份关于飞安在这些人群中发生情况的问卷。130名初中学生和138名高中学生回答了问卷。76，229名初中生中13例（男11例，女2例），104，701名高中生中9例（男6例，女3例）。此外，还检出初中生运动性过敏症24例（男12例，女12例），高中生运动性过敏症17例（男9例，女8例），其发生率分别为0.017%和0.034%，0.086%和0.016%。只有一半的学生知道费奥恩。22例实验动物中有9例在获得知情同意后进行了激发试验，证实了诊断，实验动物模型的建立尚在探索阶段。现在，我们找到了一个动物模型的候选人。还需要一段时间才能获得最终结果。这项研究表明，Feian和Eian在日本的初中和高中学生中相对较少。对于一种严重的结果和不必要的限制，它是重要的医生，但也学校的企业和体育教师熟悉的疾病。

项目成果

AIHARA, Y, TAKAHASHI Y, KOTOYORI T, MITSUDA T, ITO R, AIHARA M, IKEZAWA Z AND YOKOTA S: "FREQUENCY OF FOOD-DEPENDENT EXERCISE-INDUCED ANAPHYLAXIS IN JAPANESE JUNIOR HIGH SCHOOL STUDENTS."J ALLERGY CLIN IMMUNOL. 108. 1035-1039 (2001)

AIHARA, Y, TAKAHASHI Y, Kotoyori T, MITSUDA T, ITO R, AIHARA M, IKEZAWA Z 和 YOKOTA S：“日本初中生中食物依赖性运动引起的过敏反应的频率。”J ALLERGY CLIN IMMUNOL。

Aihara M, et al.: "F00D-DEPENDENT EXERCISE-INDUCED ANAPHYLAXIS : INFLUENCE OF CONCURRENT ASPIRIN ADMINISTRATI10N ON SKIN TESTING AND PROVOCATI0N"BR J DERMATOL. 146. 466-472 (2002)

Aihara M 等人：“F00D 依赖性运动引起的过敏反应：同时服用阿司匹林对皮肤测试和刺激的影响”BR J DERMATOL。

相原雄幸: "運動と食物アレルギー:特に食物依存性運動誘発アナフィラキシー(FEIAn)について"日本小児アレルギー学会雑誌. 17. (2003)

Yuyuki Aihara：“运动和食物过敏：特别是关于食物依赖性运动引起的过敏反应（FEIAn）”，日本儿科过敏学会杂志 17。（2003 年）

伊藤玲子ほか: "食物アレルギーが疑われる小児例におけるヒスタミン遊離試験(HRT)の有用性ならびにヒスタミンnon releaserについての検討"日本小児アレルギー学会雑誌. 16. 501-508 (2002)

Reiko Ito 等人：“组胺释放试验 (HRT) 在疑似食物过敏的儿科病例中的有用性和组胺非释放剂的研究”日本儿科过敏学会杂志 16. 501-508 (2002)。

AIHARA Y.: "EPIDEMIOLOGY OF FOOD-DEPENDENT EXERCISE-INDUCED ANAPHYLAXIS (FEIAN) AND EXERCISE-INDUCED ANAPHYLAXIS (EIAN). (IN JAPANESE)"PEDIATRICS JAPAN. 43. 759-766 (2002)

AIHARA Y.：“食物依赖性运动引起的过敏症 (FEIAN) 和运动引起的过敏症 (EIAN) 的流行病学。（日语）”日本儿科。