Growth and endocrine function among children who received bone marrow transplantation

接受骨髓移植的儿童的生长和内分泌功能

• 批准号: 11670787
• 负责人: SHINOHARA Osamu
• 金额: $ 1.86万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670787/
• 关键词: bone marrow transplantation; growth; growth hormone; gonadal function; gonadotropin; gonadal failure; thyroid function; 負荷試験; インスリン負荷試験; 甲状腺ホルモン; 甲状腺機能低下症; 小児; 成長障害; 二次性微; ゴナドトロピン; 月経

Bone marrow transplantation (BMT) has become a standard treatment for various hematological or nonhematological disorders. Since the number of long-term survivors is increasing, the effect on growth and endocrine function has become an essential issue. In this study, these matters were evaluated among children who underwent BMT.Growth failure is quite prevalent among children who received BMT. Those who had BMT at younger age had a higher risk of growth failure. The prevalence of GH deficiency was very low, and GH deficiency was not a major contributing factor for growth failure.Gonadal failure became apparent from about 10 years of age in children who underwent BMT at young age. However, about 2/3 of girls experienced menarche suggesting the favorable outcome of ovarian function in girls who receive BMT at younger age. Testosterone production was fairly preserved in the marrow recipient.Transient decrease in FT4 and TSH was observed after BMT, indicating the presence of sick euthyroid state. Thyroid function became normal within a year. Few patients developed primary hypothyroidism several years after the transplant. In conclusion, long-term assessment of growth and endocrine function is mandatory to improve the quality of life of marrow recipient.

骨髓移植（BMT）已成为各种血液学或非血液学疾病的标准治疗方法。由于长期存活者的数量不断增加，对生长和内分泌功能的影响已成为一个重要问题。在这项研究中，这些问题进行了评估的儿童接受骨髓移植。生长障碍是相当普遍的儿童接受骨髓移植。那些在年轻时接受BMT的人有更高的生长失败风险。生长激素缺乏症的患病率很低，生长激素缺乏症不是生长障碍的主要因素。在年轻时接受BMT的儿童中，性腺功能障碍从10岁左右开始明显。然而，约2/3的女孩经历了初潮，这表明在年轻时接受BMT的女孩卵巢功能的良好结果。骨髓移植受者的甲状腺素水平较正常，移植后FT_4和TSH水平出现一过性下降，提示患者甲状腺功能正常。甲状腺功能在一年内恢复正常。很少有患者在移植后几年发生原发性甲状腺功能减退症。总之，长期的生长和内分泌功能的评估是强制性的，以提高骨髓受体的生活质量。

项目成果

Matsumoto M:: "Ovarian function after bone marrow transplantation performed before menarche"Archives of Disease in Childhood. 80(5). 452-454 (1999)

松本 M：：“初潮前进行骨髓移植后的卵巢功能”儿童疾病档案。

T.Shinagawa,O.Shinohara, et.al.: "Final height and growth hormone secretion after bone marrow transplantation in children"Endocrine Journal. (in press). (2001)

T.品川，O.筱原，等：“儿童骨髓移植后的最终身高和生长激素分泌”内分泌杂志。

Sinagawa T:: "Final height and growth hormone secretion after bone marrow transplantation in children"Endocrine Journal. 45(2). 133-138 (2001)

西那川T：：《儿童骨髓移植后的最终身高和生长激素分泌》内分泌杂志。

M. Matsumoto, et al.: "Ovarian function after bone marrow transplantation performed bebore pulerty"Archives of Disease in Childhood. 80. 452-454 (1999)

M. Matsumoto 等人：“骨髓移植后的卵巢功能在童年疾病档案中进行”。

Matsumoto M, et al.: "Ovarian function after bone marrow transplantation performed before menarche"Archives of Disease in Childhood. 80. 452-454 (1999)

Matsumoto M 等人：“初潮前进行骨髓移植后的卵巢功能”儿童疾病档案。