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Analysis of flow and flow reserve in patients with arterial occlusive disease of lower extremities with MRI and CT

下肢动脉闭塞性疾病患者的血流和血流储备的MRI和CT分析

基本信息

批准号：
11670860
负责人：
SAITO Yoko
金额：
$ 1.41万
依托单位：
Hirosaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670860/
关键词：
arterial occlusive disease lower extremity femoral artery peak velocity mean flow volume magnetic resonance imaging 運動負荷血流量流速 CT 流速測定血流予備能

项目摘要

The peak velocity, mean velocity and mean flow volume of bilateral superficial femoral arteries were evaluated in patients with arterial occlusive disease of the lower extremities, using cine MRI technique with EGG gating. Those data were compared with those of normal healthy volunteers. In analysis of flow pattern, reverse flow was small in patients group, and some cases, no reverse flow was noticed. Lack of reverse flow was not noticed in any healthy volunteer.Peak velocity, mean velocity and mean flow volume increased significantly after exercise stress. Peak velocity increased in many cases and reverse flow decreased in all cases. The increase rate of peak velocity and mean velocity was higher in volunteers than in patients group, but there was no statistically significant difference between the two groups. Also no significant difference between the increase rate of mean flow volume (flow reserve) of patients and-that of healthy volunteers.The time density curves after bolus administration of contrast material were also analyzed, both in patients and health volunteers. Continuous data acquisition of both femurs was obtained during 2 minutes just after contrast material injection. The enhancement rate of skeletal muscles was lower than vessels, but higher than fat tissue. In healthy volunteers the signal of skeletal muscle increased after artery, and reached plateau 40 〜 60 seconds after the beginning of contrast material injection. In patients group, the signal intensity curve showed gradual increase pattern and in many cases showed no plateau. Therefore steepest slope values could not be obtained. No significant difference was noticed between the right side and the left side

应用EGG门控的电影MRI技术，对下肢动脉闭塞症患者双侧股浅动脉的峰值流速、平均流速和平均血流体积进行了评价。这些数据与正常健康志愿者的数据进行了比较。在流型分析中，患者组逆流较小，部分病例未见逆流。在任何健康的志愿者中都没有发现缺乏逆流。运动应激后峰值流速、平均流速和平均流量显著增加。多数情况下峰值流速增大，而所有情况下逆流速减小。志愿者组的峰值速度和平均速度增幅均高于患者组，但两组间差异无统计学意义。患者的平均流量（流量储备）增长率与健康志愿者无显著差异。同时分析了患者和健康志愿者在注射造影剂后的时间密度曲线。注射造影剂后2分钟内连续采集双股骨数据。骨骼肌的增强率低于血管，但高于脂肪组织。健康志愿者经动脉灌注后骨骼肌信号增高，在开始注射造影剂后40 ~ 60秒达到平台期。在患者组中，信号强度曲线呈逐渐增加的模式，许多病例没有平台。因此不能得到最陡的斜率值。左、右侧无明显差异