Study to assess the efficacy of a radical scavenger for the prevention of radiation enteritis

评估自由基清除剂预防放射性肠炎功效的研究

• 批准号: 11670895
• 负责人: KUNITAKE Naonobu
• 金额: $ 1.34万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670895/
• 关键词: radiation injury; radical scavenger; rebamipide; radiation enteritis

Rebamipide, which is used as a drug for gastritis and gastric ulcer, has large capability for OH radical scavenging. It is expected that rebamipide may have a protective effect against radiation enteritis after pelvic irradiation.Thirty-two patients receiving pelvic radiation therapy were randomized to rebamipide 300 mg, three tablets three times daily, or no drug. The severity of the acute radiation bowel reaction was documented by a weekly questionnaire. The Grade 0, 1, 2, 3, and 4 bowel toxicity was obseved in 4 versus 2 patients, 4 versus 3, 6 versus 8, 2 versus 4, and 0 versus 1 in the rebamipide and no-drug arms, respectively. Rebamipide seemed to be effective for diarrhea occurring during pelvic radiation therapy, but there was no statistically significant.The colorectum of C3H mice, after administration of rebamipide, were irradiated using a dose of 30 Gy and prepared for histology 15 days following irradiation. However, no significant differences were observed in mice with or without rebamipide administration.

瑞巴派特是一种治疗胃炎和胃溃疡的药物，具有很强的OH自由基清除能力。预计瑞巴派特可能对盆腔照射后的放射性肠炎具有保护作用。32名接受盆腔放射治疗的患者被随机分配至瑞巴派特300mg、3片、每日3次或不用药。通过每周问卷调查记录急性放射性肠道反应的严重程度。瑞巴派特组和无药物组分别有 4 例对 2 例患者、4 例对 3 例患者、6 例对 8 例患者、2 例对 4 例患者以及 0 例对 1 例患者观察到 0、1、2、3 和 4 级肠毒性。瑞巴派特似乎对盆腔放射治疗期间发生的腹泻有效，但没有统计学意义。C3H小鼠给予瑞巴派特后，用30 Gy的剂量照射结肠直肠，并在照射后15天准备进行组织学检查。然而，在给予或不给予瑞巴派特的小鼠中没有观察到显着差异。

项目成果

Urashima Y, Nakamura K, Shioyama Y, Kunitake N, Kimura M, Terashima H, Masuda K.: "A case of multiple pelvic insufficiency fractures following radiotherapy for cervical cancer"J. Jpn Soc Ther Radiol Oncol. 12. 255-258 (2000)

Urashima Y、Nakamura K、Shioyama Y、Kunitake N、Kimura M、Terashima H、Masuda K.：“宫颈癌放射治疗后多发性骨盆功能不全骨折一例”J。

浦島雄介, 中村和正, 塩山善之, 国武直信, 木村正彦, 寺嶋廣美, 増田康治: "支給頸癌に対する全骨盤照射後に生じた骨盤多発骨折の1症例"日本放射線腫瘍学会誌. 12. 255-258 (2000)

Yusuke Urashima、Kazumasa Nakamura、Yoshiyuki Shioyama、Naonobu Kunitake、Masahiko Kimura、Hiromi Terashima、Yasuharu Masuda：“补贴宫颈癌全骨盆照射后发生多发骨盆骨折的病例”日本放射肿瘤学会杂志12。 255-258（2000）