Proton MR Spectroscopic Imaging of Prostate Cancer. Metabolite Patterns and Response to External Beam Irradiation

前列腺癌的质子磁共振波谱成像。

• 批准号: 11670906
• 负责人: TAKEBAYASHI Shigeo
• 金额: $ 0.96万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670906/
• 关键词: Prostate cancer; MR spectroscopy; MRI; Irradiation; Citrate; Choline; コリン; クエン酸

The purpose of this study was to evaluate change in prostate metabolites after external radiation therapy in patients with prostate carcinomas. Patients with prostatic cancer underwent pelvic irradiation 66.6 Gy. MR spectroscopic imaging and the measurement of serum prostate-specific antigen (PSA) levels underwent before irradiation therapy, at 33.2 Gy irradiation, 2 weeks-post irradiation and 10 weeks-post irradiation. A two dimensional 7 x 7 phase encoded MR spectroscopic imaging data set was acquired by a 1.5-T system with the body coil for radio-frequency transmission and an expandable endorectal coil. According to comparisons between citrate and choline peak levels, the metabolite patterns of the prostate were classified into citrate dominant, choline dominant and equilibrium pattern in which choline peak level is lower than citrate level but more than 90 % of citrate level.The mean area with choline dominant pattern before irradiation was 1.86 〓 1.18 cm3. Choline dominant areas were remained after irradiation although those at 2 and 10 weeks-postirradiation were significantly decreased to 0.85 〓 0.72 cm3 (p = 0.03) and 0.73 〓 0.40 cm3 (p = 0.01), respectively.

本研究的目的是评估前列腺癌患者外照射治疗后前列腺代谢物的变化。前列腺癌患者接受盆腔放疗66.6Gy.放射治疗前、照射后33.2Gy、照射后2周、照射后10周分别进行磁共振波谱成像和血清前列腺特异性抗原(PSA)水平的测定。用1.5T系统采集二维7×7位相编码的磁共振波谱成像数据集，采用射频传输的体线圈和可扩展的直肠内线圈。根据柠檬酸和胆碱峰浓度的比较，前列腺的代谢产物类型可分为柠檬酸主导型、胆碱主导型和平衡型，其中胆碱主导型低于柠檬酸盐但超过90%，照射前胆碱主导型的平均面积为1.86〓1.18cm3。胆碱优势区在照射后2周和10周分别降至0.85cm3(p=0.03)和0.73〓0.40cm3(p=0.03)，但仍保持不变。