Nocturnal Myoclonus in Refractory Akathisia -A Polysomnographic Study on Drug Treatment and the Pathogenesis-

难治性静坐不能的夜间肌阵挛-药物治疗及其发病机制的多导睡眠图研究-

• 批准号: 11670945
• 负责人: HORIGUCHI Jun
• 金额: $ 1.98万
• 依托单位: Shimane Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670945/
• 关键词: nocturnal myoclonus; akathisia; periodic limb movement disorder; polysomnography; psychiatric drug treatment; sleep; 終夜睡眠ポリグラフィー; 電気生理学

1) Schizophrenic patients with and without akathisia underwent whole-night polysomnographic recordings before and during the drug treatment.2) In the present study, we quantitated the change of the polysomnographical findings, especially nocturnal myoclonus, before and during the drug treatment to investigate the relationship between akathisia and nocturnal myoclonus.3) We found that the drug treatment to akathisia significantly decreased the total numbers of bilateral nocturnal myoclonus and the numbers of bilateral nocturnal myoclonus per hour with the subjective improvement of akathisia and that the characteristics of sleep disturbance in akathisia were the disturbance of sleep maintenance and the decrease of %stage III and IV.Our data suggest the causal relationship between akathisia and nocturnal myoclonus.

1)精神分裂症伴无静坐症患者在药物治疗前和治疗期间进行通宵多导睡眠图记录。2)在本研究中，我们量化了药物治疗前和治疗期间多导睡眠图的变化，特别是夜间肌阵挛的变化，以探讨肌阵挛与静坐症的关系。3)我们发现，药物治疗能显著降低双侧夜间肌阵挛的总次数和每小时双侧夜间肌阵挛的次数，随著静坐症的主观改善，静坐症的睡眠障碍特征是睡眠维持障碍和% III期和iv期的减少。我们的数据提示静坐症与夜间肌阵挛之间存在因果关系。

项目成果

水野創一: "Restless Legs Syndromeの診断上の問題点"新薬と臨床. 49・3. 211-214 (2000)

Soichi Mizuno：“不安腿综合症的诊断问题”新药和临床实践49・3（2000）。

Soichi Mizuno: "Restless Legs Syndrome and Neuroleptics"J.New Rem. & Clin. 49. 236-243 (2000)

Soichi Mizuno：“不宁腿综合症和抗精神病药”J.New Rem。

Tsuyoshi Miyaoka: "Reversible Pitch Perception Deficit Caused by Carbamazepine"Clinical Neuropharmacology. 23・4. 211-221 (2000)

Tsuyoshi Miyaoka：“卡马西平引起的可逆性音调感知缺陷”临床神经药理学211-221（2000）。

水野創一: "抗精神病薬とRestless Legs Syndrome"新薬と臨床. 49・3. 236-243 (2000)

Soichi Mizuno：“抗精神病药和不安腿综合症”新药和临床实践49・3（2000）。

Tsuyoshi Miyaoka: "Contribution of sodium valproate to the syndrome of inappropriate secretion of antidiuretic hormone"International Clinical Psychopharmacology. 16・1. 59-61 (2001)

Tsuyoshi Miyaoka：“丙戊酸钠对抗利尿激素分泌异常综合征的作用”国际临床精神药理学16・1（2001）。