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Electrophysiological studies of myoclonus "during wakefulness" for understanding the pathophysiology of akathisia.

“清醒期间”肌阵挛的电生理学研究，以了解静坐不能的病理生理学。

基本信息

批准号：
21591485
负责人：
HORIGUCHI Jun
金额：
$ 2.91万
依托单位：
Shimane University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

The total number of patients who were admitted to the hospital during this study was 132 people. 27 people of the 132 hospitalized patients had been diagnosed with schizophrenia based on the DSM-IV diagnostic criteria. Four out of the 27 patients expressed akathisia during the hospitalization. The total number of patients with schizophrenia during this study period was 55 people with an average age of 37 years. The akathisia patients totaled 11 people of the 55 people with schizophrenia. The incidence of akathisia was 20. 0% overall. Yi-gan san(7. 5g/day, 3times/day before meals) was administered to three patients whose akathisia did not improve when using akathisia treatment guidelines. In addition, akathisia did not improve even after the administration of Yi-gan san to the three mentioned patients. Examples of polysomnography were 24 cases. In three of these cases it was possible to shoot using a video camera.Therefore, the patient was able to extract myoclonus "during wakefulness" this being the case in only three cases. The level of achievement against the original plan and purpose was delayed. All eligible patients had already started taking many types of antipsychotic drugs before the study period, and therefore the incidence of akathisia could not be due to a simple comparison of the prevalence of "myoclonus during wakefulness".

在这项研究期间，住院的患者总数为132人。132名住院患者中有27人根据DSM-IV诊断标准被诊断为精神分裂症。27名患者中有4名在住院期间表现出静坐不能。研究期间的精神分裂症患者总数为55人，平均年龄为37岁。在55名精神分裂症患者中，静坐不能患者共计11人。静坐不能的发生率为20.0%。3例静坐不能改善的患者在使用静坐不能治疗指南时，服用益肝散7.5克/天，3次/天，饭前服用。此外，静坐不能即使在上述三个患者服用益肝散后也没有改善。多导睡眠图24例。在这些病例中，有3例可以使用摄像机拍摄。因此，患者能够在“清醒时”提取肌阵挛，这种情况只有3例。与原计划和目的相违背的成就水平被推迟。所有符合条件的患者在研究期间之前已经开始服用多种类型的抗精神病药物，因此静坐不能的发生率不可能是简单地比较“清醒时肌阵挛”的患病率。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effect of levothyroxine on prolonged nocturnal sleep time and excessive daytime somnolence in patients with idiopathic hypersomnia

左旋甲状腺素对特发性嗜睡症患者夜间睡眠时间延长和白天过度嗜睡的影响

DOI：
10.1016/j.sleep.2011.02.004
发表时间：
2011
期刊：
Sleep Medicine
影响因子：
4.8
作者：
Hideto Shinno;Ichiro Ishikawa;Mami Yamanaka;Ai Usui;Sonoko Danjo;Yasushi Inami;Jun Horiguchi;Yu Nakamura
通讯作者：
Yu Nakamura

Sleep Stage Transitions in Healthy Humans Altered by Central Monoaminergic Anatagonist

中枢单胺能拮抗剂改变健康人的睡眠阶段转变