Histopathologic Effects of Neoadjuvant Therapy for Esophageal Cancer and p53 status

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1. In the chemoradiotherapy group, the pathologic response rate was 86.4%, and was significantly higher than that for chemotherapy (p<0.0001), or for radiotherapy (p=0.0031).2. In patients with normal p53 protein expression, the histopathologic response rate to chemotherapy was 20.0%, a significantly higher rate than that for patients with abnormal p53 overexpression. In the chemoradiotherapy or radiotherapy group, however, the histopathologic response rates were almost the same irrespective of p53 oncoprotein status.3. From multivariate analysis, the neoadjuvant treatment modality was identified as the most powerful predictive factor for the histopathologic effect of neoadjuvant treatment (p=0.0002). Other identified predictive factors were the absence of "blood vessel invasion" and "intramural metastasis".4. Direct sequencing of genomic DNA of esophageal cancer did not always coincide with the results of immunohistochemical staining of p53 protein.