权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

An experimental study on the influence of spinal shortening on the spinal cord

脊柱缩短对脊髓影响的实验研究

基本信息

批准号：
11671425
负责人：
TOMITA Katsuro
金额：
$ 1.54万
依托单位：
kanazawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671425/
关键词：
total spondylectomy spinal shortening spinal reconstruction 脊柱変形脊柱再建

项目摘要

Spinal column shortening is one of the effective modality in reconstruction of total spondylectomy. We studied morphometric and physiologic changes of the spinal cord in spinal column shortening using animal models.[Methods] Total spondylectomy of T12 was performed after 2 above and 2 below spinal instrumentation in 16 dogs. Spinal column was gradually shortened until the lower endplate of the T11 contacted onto the L1 upper endplate (maximum of 20 mm).[Results] The dural sac and the spinal cord did not change their shapes until 8 mm (44%) shortening. From 8 mm to 11.5 mm (64%) shortening, the dural sac was deformed like an accordion while the spinal cord maintained its shape. In more than 11.5 mm shortening, the dural sac buckled and became like spanworm, and the spinal cord was compressed by the buckled dura in its concave side. In the spinal cord evoked potentials study, no significant changes could be seen until 11.5 mm shortening, but augmentation of amplitude was recorded at more than 11.5 mm shortening. At 20 mm (100%) shortening, positive going potentials were seen at the level of upper endplate of the L1 vertebra.[Conclusion] The morphometric change of the spinal cord and the dural sac in association with spinal column shortening can be characterized in three phases ; (phase 1) no deformity of the dural sac and the spinal cord, (phase 2) shrinking and buckling of the dural sac, (phase 3) spinal cord deformity and compression by the buckled dura. The phase 1 is the safety range of for the spinal cord. The phase 2 is the warning range, and the phase 3 is the critical range.

脊柱短缩术是全椎体切除后重建的有效方法之一。我们用动物模型研究了脊髓在脊柱缩短过程中的形态和生理变化。[方法]对16只犬进行2上2下脊柱内固定后的T12全椎体切除术。脊柱逐渐缩短，直到T11下终板与L1上终板接触（最大20mm）。[结果]硬脊膜囊和脊髓在缩短8mm（44%）后形态才发生改变。从8mm缩短到11.5 mm(64%)，硬脑膜囊像手风琴一样变形，而脊髓保持其形状。在超过11.5 mm的缩短中，硬脑膜囊屈曲，变成了蚓状，脊髓被屈曲的硬脑膜挤压在其凹侧。在脊髓诱发电位研究中，在缩短11.5 mm之前未见明显变化，但在缩短11.5 mm以上时记录到振幅增强。在缩短20mm（100%）时，L1椎体上终板水平可见正电位。[结论]脊髓及硬脊膜囊与脊柱短缩相关的形态改变可分为三个阶段；（第一阶段）硬脑膜囊和脊髓无畸形，（第二阶段）硬脑膜囊萎缩和屈曲，（第三阶段）脊髓畸形和硬脑膜屈曲压迫。第一阶段是脊髓的安全范围。阶段2为预警范围，阶段3为临界范围。