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Post longitudinal extension of spinal cord injury in spinal and section and contusion

脊髓损伤后纵向延伸、切片和挫伤

基本信息

批准号：
18591625
负责人：
TOMITA Katsuro
金额：
$ 2.04万
依托单位：
Kanazawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591625/
关键词：
spinal cord injury spinal cord section spine tumor 腫瘍脊髄骨全摘術脊髄腫瘍

项目摘要

The present study evaluated post longitudinal extension of spinal cord injury in spinal cord section and contusion.Six dogs were used for the experiments of the acute phase and divided into two groups ; spinal cord section and spinal cord contusion. Spinal cord evoked potentials (SCEP) and Motor evoked potentials (MEP) were measured immediately after spinal cord oration and contusion. In the spinal cord section, the amplitudes of the SCEP decreased 2cm above section immediately after spinal cord section. In the spinal cord contusion, the amplitudes of the SCEP decreased 2 cm above contusion immediately attar spinal cord contusion.Six dogs were used for the experiments of the chronic phase and divided into two groups ; spinal and section and spinal cord contusion. SCEP and MEP were measured one week after spinal cord section and contusion. In the spinal cord section, the amplitudes of the SCEP decreased 3.5≠±0.3 cm above section one week after spinal cord oration. In the spinal cord contusion, the amplitudes of the SCEP decreased 25±0.5cm above contusion one week after spinal cord contusion.Histology and microscopy of the dogs one week after spinal cord section and contusion were evaluated. In the spinal cord section, white and gray matter damage was seen 2-4 cm above spinal cord section. In the spinal cord contusion, a "tooth paste phenomenon" was recognized pathologically. This is a phenomenon that occurs when parenchymal tissue of spinal cord is squeezed and penetrates above and below the level of compression. Gray matter damage was seen 2-4 cm above spinal cord contusion. We considered that spinal cord section compressed spinal cord like spinal contusionBecause such a tooth paste phenomenon occurs when a spinal cord is ligated, transaction with a scalpel, instead of ligation, is desirable to avoid damaging spinal cord. The present study suggests that secondary spinal cord injury occurs several days after spinal cord injury.

本研究评估脊髓纵伸损伤后脊髓切片和挫伤。急性期实验用6只狗，分为两组；脊髓切片和脊髓挫伤。脊髓损伤和挫伤后立即测定脊髓诱发电位（SCEP）和运动诱发电位（MEP）。在脊髓切片中，SCEP振幅在脊髓切片后立即下降2cm。在脊髓挫伤中，SCEP的振幅在挫伤上方立即下降2cm。慢性期实验选用6只狗，分为两组；脊髓和部分脊髓挫伤。脊髓切片及挫伤后1周测定SCEP和MEP。脊髓缝合1周后，脊髓切片SCEP振幅下降3.5≠±0.3 cm。脊髓挫伤1周后SCEP振幅比挫伤高25±0.5cm。对脊髓切片和挫伤后1周的组织学和显微镜观察进行评价。脊髓切片上，2 ~ 4 cm可见白质和灰质损伤。在脊髓挫伤中，病理上发现了一种“牙膏现象”。这是一种脊髓实质组织受到挤压并穿透压迫层上方和下方时发生的现象。脊髓挫伤上方2-4 cm可见灰质损伤。我们认为脊髓切片压缩脊髓与脊髓挫伤类似，因为脊髓结扎时出现这种牙膏现象，因此最好用手术刀处理，而不是结扎，以避免损伤脊髓。本研究提示继发性脊髓损伤发生在脊髓损伤后数天。