Quantitative Evaluation for Structural Recovery of Injured Tendons with a New Magnetic Resonance Imaging

本项目的目的是用一种新的磁共振成像对损伤的跟腱进行定量评估。1)DQF-核磁共振图像：在肌腱切断后3周，损伤的跟腱在DQF-核磁共振图像上显示不出来。但是，虽然受伤的跟腱正在成熟，但在DQF-核磁共振图像上，来自受伤的跟腱的信号变得更高。常规MRI无法将损伤的肌腱与其他正常肌腱区分开来。通过优化创建时间(τ)2)DQF-核磁共振图像，这种区别是明显的：在肌腱切断后3周，没有检测到来自损伤跟腱的信号。但随着跟腱损伤的逐渐成熟，损伤跟腱的DQF-核磁共振信号强度增强，其强度与跟腱损伤后胶原纤维的数量和排列顺序有关，t_t；max&gt；3)组织学表现：随着跟腱损伤程度的加深，损伤肌腱组织中胶原纤维的排列顺序变高，利用DQF-核磁共振成像方法可以定量评价损伤跟腱组织中胶原纤维的排列顺序，并可将亚慢性损伤跟腱与其他完整肌腱区分开来。

The aim of this project is the quantitative evaluation of injured tendons with a new magnetic resonance imaging.1) DQF-NMR image : At 3 weeks after tenotomy, the injured Achilles tendon was not depicted on the DQF-NMR image. But, while injured Achilles tendons are maturing, the signal from injured Achilles tendons became higher on the DQF-NMR image. With the conventional MRI, the injured tendon could not be distinguished from other normal tendons. With the DQF-NMR image, this distinction was clear by optimizing the creation time (τ).2) DQF-NMR signal : At 3 weeks after tenotomy, the signals from injured Achilles tendons were not detected. But, while injured Achilles tendons were maturing, the intensity of DQF-NMR signals from injured Achilles tendons, which was related with the amount and the order of collagen fibers in injured Achilles tendons, became higher and t_<max> of DQF-NMR signals, which was related with the order of collagen fibers, became shorter.3) Histological findings : While injured Achilles tendons were maturing, the order of collagen fibers in the part of injured tendon tissues became higher.With using a DQF-NMR imaging method, the order of collagen fibers in injured tendon tissues could be evaluated quantitatively, and injured Achilles tendons at a subchronic phase could be clearly distinguished from other intact tendons.