Changes in the expression of adenylyl cyclase and G-protein mRNA and the regulation system in myometrium
子宫肌层腺苷酸环化酶和G蛋白mRNA表达及调控系统的变化
基本信息
- 批准号:11671639
- 负责人:
- 金额:$ 2.18万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1999
- 资助国家:日本
- 起止时间:1999 至 2000
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1 Expression of adenylyl cyclase (AC) and G-protein mRNAs in rat myometrium during the course of pregnancy and after delivery● The level of expression of ACs (AC2, AC4, AC6, AC7 and AC9) increased during the course of pregnancy and diminished near term and after delivery. The highest level of expression in each type of AC was consistently seen on day 17 of pregnancy.● The level of expression of Gs protein increased only on day 17 of pregnancy, and it did not change on the other dates.2 AC activities in rat myometrium during the course of pregnancy and after delivery● In agreement with above findings, both basal and forscolin-stimulated AC activities increased during the course of pregnancy and diminished near term and after delivery.3 Changes in the expression of AC and G-protein mRNAs in rat castrated and hormone administrated model● The expression of AC2, AC4 and AC9 mRNAs increased by estrogen (E), E and progesterone (P) and P, respectively.● The expression of AC6 and AC7 mRNAs did not change by E or P.● The expression of Gs mRNAs increased by P.4 Expression of AC mRNAs in rat model that is pregnant only in the one side of the uterus● The expression of AC2 mRNAs increased in the pregnant side coropared to that in the non-pregnant side.● The expression of AC4, AC6, AC7 and AC9 mRNAs did not change in the both pregnant and non-pregnant sides.These results suggest that1. The expression of ACs and Gs mRNAs is influenced by the different sex hormones.2. There is a possibility that the expression of AC mRNAs is influenced by several factors except to estrogen and progesterone.3. The expression of AC2 mRNA seeros to induct by the local secretion of several hormones or the stretched stimulation.
1 孕期和产后大鼠子宫肌层腺苷酸环化酶(AC)和G蛋白mRNA的表达 ● ACs(AC2、AC4、AC6、AC7和AC9)的表达水平在孕期升高,近足月和产后降低。各类型 AC 的最高表达水平一致出现在妊娠第 17 天。 ● Gs 蛋白表达水平仅在妊娠第 17 天增加,在其他日期没有变化。2 妊娠期间和分娩后大鼠子宫肌层的 AC 活性● 与上述结果一致,基础和毛喉素刺激的 AC 活性在妊娠期间增加,近期和分娩后减少。3 AC 和 F 表达的变化 大鼠去势和激素给药模型中 G 蛋白 mRNAs ● 雌激素 (E)、E、孕酮 (P) 和 P 分别增加 AC2、AC4 和 AC9 mRNA 的表达。 ● E 或 P 不改变 AC6 和 AC7 mRNA 的表达。 ● P 增加 Gs mRNA 的表达。 4 仅一侧子宫妊娠大鼠模型中 AC mRNA 的表达 ● 表达 妊娠侧AC2 mRNA的表达较非妊娠侧增加。 ●妊娠侧和非妊娠侧AC4、AC6、AC7和AC9 mRNA的表达均无变化。这些结果表明: 1. ACs和Gs mRNA的表达受不同性激素的影响。 2.除了雌激素和孕激素外,AC mRNA的表达可能还受到多种因素的影响。 3. AC2 mRNA的表达受多种激素的局部分泌或拉伸刺激诱导。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SUZUKI Yosuke其他文献
広視野近赤外線望遠鏡PRIMEの光学調整と試験観測
大视场近红外望远镜PRIME光学调整及测试观测
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
OPERA Collaboration (N. Agafonova (Moscow;INR) et al.).;村田樹;SUZUKI Yosuke;山響 - 通讯作者:
山響
SUZUKI Yosuke的其他文献
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{{ truncateString('SUZUKI Yosuke', 18)}}的其他基金
Development of modular robot system generating locomotion and control function in an identical structure
开发在相同结构中产生运动和控制功能的模块化机器人系统
- 批准号:
22860025 - 财政年份:2010
- 资助金额:
$ 2.18万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Digital X-ray equipment with double arms for handicapped person.
供残疾人使用的双臂数字X射线设备。
- 批准号:
17591972 - 财政年份:2005
- 资助金额:
$ 2.18万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The development of the portable x-ray equipment for dentistry.
便携式牙科X射线设备的开发。
- 批准号:
09671930 - 财政年份:1997
- 资助金额:
$ 2.18万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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