The role of tyrosine in invasion and metastasis of ovarian carcinoma

酪氨酸在卵巢癌侵袭和转移中的作用

• 批准号: 11671641
• 负责人: HIRAHARA Fumiki
• 金额: $ 2.24万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671641/
• 关键词: invasion; metastasis; ovarian carcinoma; trypsin; 卵巣ガン; 浸潤転移; PP5; TFDI-2; 浸潤・転移; PPS; トップシン

PP5/TFPI-2/MSP is a serine protease inhibitor with broad inhibitory spectra, produced by placenta and tumor cells. To investigate this inhibitory substance in malignant progression and placental implantation, human trophoblastic tumor cell lines were transected with human PP5/TFPI-2/MSP expression vector and stable clones were established.The results revealed that its expression did not affect growth and migration of the tumor cells, but enhanced their plating efficiency. In addition, its expression inhibited invasion through Matrigel.Conclusions; PP5/TFPI-s/MSP expression showed suppressed potentials in invasion of tumor cells.

PP 5/TFPI-2/MSP是一种丝氨酸蛋白酶抑制剂，具有广泛的抑制谱，由胎盘和肿瘤细胞产生。为探讨该物质在恶性进展和胎盘植入中的作用，将人PP 5/TFPI-2/MSP表达载体转染人滋养细胞肿瘤细胞系，建立了稳定的克隆，结果表明，PP 5/TFPI-2/MSP的表达不影响肿瘤细胞的生长和迁移，但提高了肿瘤细胞的植板效率。结论：PP 5/TFPI-s/MSP的表达具有抑制肿瘤细胞侵袭的作用。

项目成果

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Udagawa K et al.: "Subcellular localization of PP5/TFPI-2 in human placenta"Placenta. 23. 145-153 (2002)

Udakawa K 等人：“人胎盘中 PP5/TFPI-2 的亚细胞定位”胎盘。

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Udagawa K et al.: "Subcellular localization of PP5-TFPI2 in human placenta"Placenta. 23. 145-153 (2002)

Udakawa K 等人：“PP5-TFPI2 在人胎盘中的亚细胞定位”胎盘。