THE INHIBITORY EFFECT OF FETAL ADENOSINE ON THE PRODUCTION OF TUMOR NECROSIS FACTOR ALPHA.

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[PURPOSE] The purpose of this study is to evaluate the inhibitory effect of fetal adenosine on production of tumor necrosis factor-α(TNF-α).[METHOD] We measured plasma adenosine and TNF-α concentrations in the fetuses and preeclamptic women, and then evaluate the relationship between them.[RESULTS] The elevation of plasma adenosine was associated with the inhibitory effect of production of TNF-α.[CONCLUSION] This study has suggested that plasma adenosine may play role in the regulation of TNF-α, which eventually dampens to worsen the pathologic conditions of fetuses and preeclamptic women.