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Experimental study on mechanism of positional vertigo using the non-otolithic vestibular organ.

非耳石前庭器官位置性眩晕机制的实验研究

基本信息

批准号：
11671704
负责人：
MAMORU Suzuki
金额：
$ 2.62万
依托单位：
Tokyo Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671704/
关键词：
positional vertigo canalolithiasis otoconia cupula semicircular canal action potential

项目摘要

Mechanism of positional vertigo was studied using isolated labyrinth of the bull frog. Canalolithiasis and cupulolithiasis models were established using the saccular otoconia as responsible debris inside of the canal and on the cupula respectively. The action potentials of the ampullary nerve were recorded using glass suction electrode. The latency and time course of the responses were comparable to those of clinical course of positional nystagmus. Thus, canalolithiasis is a potential mechanism of positional vertigo. Vertigo as a primary symptom increases according to the speed of head changing. This phenomenon was studied using canalolithiasis model. The faster the change of canal position, the greater the action potentials, indicating the hair cells respond to acceleration of the moving debris. Elastase was injected into the inner ear of the guinea pigs in order to dislodge the otoconia from the macula. The animals showed positional nystgmus after surgery. Vibration was given to the bony bulla of the guinea pigs in order to establish a model of positional vertigo after middle ear surgery. The saccular otoconia were dislodged from the macula, thus indicating surgical drilling being a possible cause of positional vertigo.

本文用牛蛙迷路模型研究了位置性眩晕的发生机制。分别以囊状耳石作为耳道内和耳杯上的责任碎屑，建立耳道结石和耳杯结石模型。用玻璃吸引电极记录壶腹神经动作电位。反应的潜伏期和时间过程与位置性眼震的临床过程相当。因此，泪小管结石是位置性眩晕的一个潜在机制。眩晕作为主要症状，根据头部变化的速度而增加。利用肾管结石模型研究了这一现象。毛管位置变化越快，动作电位越大，表明毛细胞对运动碎片的加速反应。将弹性蛋白酶注射到豚鼠的内耳中，以将耳石从黄斑中取出。手术后动物出现位置性眼球震颤。采用振动法建立豚鼠中耳手术后位置性眩晕模型。囊状耳锥从黄斑脱落，因此表明手术钻孔可能是位置性眩晕的原因。