Experimental study on the changes and regeneration of the cupula due to ototoxic drugs.

耳毒性药物引起的杯托变化及再生的实验研究。

• 批准号: 15591833
• 负责人: SUZUKI Mamoru
• 金额: $ 1.86万
• 依托单位: Tokyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591833/
• 关键词: cupula; semicircular canal; otoconia; positional vertigo; Gentamicin; cupulolithiasis; canalolithiasis; 回転刺激; 膨大部; 感覚細胞; 振子様回転; 活動電位

The effects of the changes in physical property of the semicircular canal cupula were studied Mechanical vibration to the middle ear induced detachment of the utricular otoconia both in bull frogs and mammals. The otoconia moved into semicircular canal lumen. This condition was regarded as a model of canalolithiasis of BPPV. When the otoconia were attached to the cupula surface, this was cupulolithiasis model. Both models suppressed the canal nerve activity induced by sinusoidal rotatory stimulus. This is considered to be a mechanism of decreased caloric response and VOR in BPPV patients. Gentamicin was injected into bullfrogs' inner ear and changes of the cupula were studied. The cupula was shrunken into about half size. However, the viscous nature of the cupula surface was maintained. Decreased cupula volume allows easy deflection upon head change, thus possibly leading to the occurrence of positional vertigo. Decreased cupula volume also allows the endolymph escape through ampullary wall, thus possibly leading to vertigo after canal plugging procedure.

本文研究了半规管顶物理性质的变化对机械振动诱发牛蛙和哺乳动物中耳椭圆囊耳圆锥脱离的影响。耳石移位入半规管腔。这种情况被认为是BPPV的小管结石模型。当耳石附着于耳杯表面时，即为耳杯结石模型。两种模型均能抑制正弦旋转刺激引起的神经管活动。这被认为是BPPV患者热量反应和VOR降低的机制。将庆大霉素注入牛蛙内耳，观察牛蛙内耳顶的变化。吸盘缩小到一半大小。然而，吸盘表面的粘性保持不变。壶腹体积减小，换头时容易偏斜，可能导致体位性眩晕的发生。壶腹体积的减少也允许内淋巴通过壶腹壁逃逸，因此可能导致椎管堵塞手术后的眩晕。

项目成果

Caloric response after lateral semicircular canal plugging.

外侧半规管堵塞后的热量反应。

• 发表时间: 2003
• 期刊: Equilibrium Research 62
• 作者: M.Suzuki;et al.
• 通讯作者: et al.

Experimental Study of Speed-dependent Positional Nystagmus in Benign Paroxysmal Positional Vertigo

• DOI: 10.1080/00016480310015010
• 发表时间: 2003-06
• 期刊: Acta Oto-Laryngologica
• 影响因子: 1.4
• 作者: M. Furuya;Mamoru Suzuki;Harushiro Sato

半規管遮断術後の温度眼振反応

半规管阻断后温度性眼球震颤反应

• 发表时间: 2003
• 期刊: Equilibrium Research 62
• 作者: 鈴木 衞;小川恭生;竹之内剛
• 通讯作者: 竹之内剛

鈴木 衛: "半規管遮断術後の温度振反応"Equilibrium Research. 62・3. 190-193 (2003)

铃木守：“半规管封锁后的温度震颤反应”平衡研究62・3（2003）。