Central control and adaptive mechanisms in vergence eye movement

关于集中眼动的神经机制，特别是与适应有关的知识仍然很少，而不是过去十年的努力。在这项研究中，我对聚焦和相关的眼球运动进行了心理物理和脑成像研究。在心理物理研究中，1)利用计算机辅助立体刺激的双步骤范式，发现了在趋同和追随上的适应性变化。利用红外线边缘跟踪器监测眼球运动；2)分析运动背景对中心目标收敛的影响。(投资。眼科。维。科学，2001；视觉研究，2001；投资。眼科。维。SCI，2001)。在PET研究中，立体刺激是通过带有眼动监测器的头戴式立体显示器给出的。V5、顶下回、枕外回和梭形回被激活(NeuroImage，1999)。在功能磁共振成像研究中，小脑激活可见于丘脑(VI和VII)和大脑半球。这些结果表明，运动指令生成器，而不是视觉-运动整合的场所，负责聚焦和追逐眼动的适应性变化。

The knowledge on neural mechanisms of vergence eye movement, especially in relation to adaptation, is still poor, instead of efforts in the last decade. In this study, I performed psychophysical and brain imaging studies on vergence and related eye movements. In psychophysical studies, 1) adaptive changes in vergence as well as pursuit were found by double step paradigm using computer-assisted stereoscopic stimuli. Eye movement was monitored by an infrared limbus tracker ; and 2) effects of the moving background on vergence evoked by a central target were analyzed. (Invest. Ophthalm. Vis. Sci., 2001 ; Vision Research, 2001 ; Invest. Ophthalm. Vis. Sci, 2001). In PET studies, stereoscopic stimuli were given through a stereoscopic head-mounted display with an eye movement monitor. V5, inferior parietal, lateral occipital and fusiform gyri were activated (NeuroImage, 1999). In fMRI studies, cerebellar activation in vermis (VI and VII) and hemisphere were revealed. Based on these results, it is indicated that the motor command generators, rather than the sites for visuo-motor integration, are responsible for adaptive changes in vergence and pursuit eye movements.