Change in Brain Blood Flow before and after Chewing Using Near-Infrared Spectroscopy

使用近红外光谱法观察咀嚼前后脑血流量的变化

• 批准号: 11671959
• 负责人: ARAKAWA Ichiro
• 金额: $ 2.3万
• 依托单位: The Nippon Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671959/
• 关键词: Masticatory Movement; Brain Blood Flow; Surface Blood Flow; Masseter Muscular Activity; Near-Infrared Spectroscopy

The purpose of this experiment was to clarify the relationship between masticatory movement and brain blood flow.Forty healthy subjects (20 males and 20 females) in their twenties were asked to chew a piece of chewing gum on their habitual chewing side. The masseter muscular activity using EMG, the surface blood flow using laser bloody flow meter, and the deep blood flow of the forehead and temporal region using NIRS (Near-infrared spectroscopy) were recorded simultaneously. The change of the deep blood flow of the forehead and the temporal region during mastication were investigated and then compared between the amount of blood flow in the brain and the integral values of masseter muscular activities.Though the surface blood flow of the forehead did not change during mastication, the deep blood flow of the forehead increased during mastication and returned to its original state. It was confirmed that the device used in this experiment could detect the brain blood flow without the influence of muscular activity, and the probe of the anterior temporal region also could detect the brain blood flow.The brain blood flow increased during mastication and decreased when mastication ceased and returned to its original state. And the integral values of masseter muscular activity and the blood flow in the brain were smallest at weak period and increased in order of medium period and strong period. A significant difference was found between the periods. From, these results it was concluded that the blood flow in the brain did increase by masticatory movement and the strength of the muscular activity affected the changes of brain blood flow.

为探讨咀嚼运动与脑血流的关系，本实验选取40名20岁左右的健康受试者（男20名，女20名），在其习惯咀嚼的一侧咀嚼一块口香糖。同时记录咬肌肌电活动、激光血流量计表面血流量、近红外光谱仪额颞部深部血流量。结果表明：咀嚼运动中额部表层血流量无明显变化，但额部深层血流量在咀嚼过程中增加并恢复到原来的状态;实验证实，本实验所用的装置可以在不受肌肉活动影响的情况下检测脑血流量，前颞区探头也可以检测脑血流量，咀嚼时脑血流量增加，咀嚼停止恢复时脑血流量减少。咬肌活动积分值和脑血流量积分值在弱期最小，在中、强期依次增大。两个时期之间存在显著差异。结果表明，咀嚼运动确实使脑血流量增加，咀嚼肌活动强度影响脑血流量的变化。

项目成果

Yoshinori Kobayashi et al.: "Change in brain blood flow during gum chewing"9th Meeting of the International College of Prosthodontists, Program and Abstracts of Papers. 42 (2001)

Yoshinori Kobayashi 等人：“咀嚼口香糖时脑血流量的变化”国际修复医师学院第九次会议，会议议程和论文摘要。

荒川 一郎 他: "チューインガム咀嚼時における咬筋筋活動量と側頭部の深部血流との関係"日本補綴歯科学会雑誌. 44・104回特別号. 143 (2000)

Ichiro Arakawa 等人：“咀嚼口香糖时咬肌活动与颞部深层血流的关系”，日本口腔修复学会杂志第 44 期/第 104 期特刊（2000 年）。

Ichiro Arakawa, Hiroshi Shiga, Yasuharu Shonai, Yoshinori Kobayashi: "Relationship between muscular activity and brain blood flow during chewing"Journal of Dental Research. (in printing).

Ichiro Arakawa、Hiroshi Shiga、Yasuharu Shonai、Yoshinori Kobayashi：“咀嚼时肌肉活动与脑血流的关系”牙科研究杂志。

Ichiro Arakawa et al.: "Relationship between muscular activity and brain blood flow during chewing"Journal of Dental Research. (発表予定).

Ichiro Arakawa 等人：“咀嚼过程中肌肉活动与脑血流量的关系”《牙科研究杂志》（待出版）。

Ichiro Arakawa, Hiroshi Shiga, Yoshinori Kobayashi, Mika Unno: "The Relationship between Masseter Muscular Activities and Deep Blood Flow of Temporal Area in Masticating Chewing Gum"J Jpn Prosthodont Soc. 44 (104th Special Issue). 143 (2000)

Ichiro Arakawa、Hiroshi Shiga、Yoshinori Kobayashi、Mika Unno：“咀嚼口香糖时咬肌肌肉活动与颞区深层血流的关系”Jpn Prosthodont Soc。