ESTIMATION OF FLUORIDE ANALYSIS FOR FOOD BY MICRODIFFUSION METHOD

微扩散法估算食品中的氟化物分析

• 批准号: 11672059
• 负责人: KOGA Hiroshi
• 金额: $ 1.54万
• 依托单位: TOKYO DENTAL COLLEGE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11672059/
• 关键词: daily fluoride intake; microdiffusion method; fluoride analyssis; adequate intake; 食品; 微量拡散法; 食品中フッ化物濃度; フッ化物

To establish the criteria of individual daily fluoride intakes (DFIs), fluoride analysis is necessary to ascertain the adequate intake (AI) of fluoride with available world-wide basis. These data are to have a monitoring of fluoride intake in terms of fluoride application for the prevention of dental caries and oral diseases. The purpose of this study was to estimate DFIs for food samples of infant formula, baby food and daily foods available commercially. Fluoride was determined by hexamethyldisiloxane(HMDS)-microdiffusion method at 60℃ for 12hr over. Fluoride concentrations of infant formula (ready-to feed) with 0.1ppm fluoride drinking water ranged from 0.14 to 0.22ug/ml (mean 0.17ug/ml, h=10), and fluoride contents of coreal, meat and fish, vegetable as baby food and juice showed mean value of 0.30 (n=11), 0.13(n=20), 0.17 (n=11) and 0.10ug/g (n=6), respectively. On the other hand mean fluoride concentration of each food group showed that 0.05ug/g in milks, 0.08ug/g in egg, 0.023ug … More /g in fish and meat, 0.06ug/g in vegetables, 0.02ug/g in potatoes and starches, 0.07ug/g in fruits, 0.14ug/g in cereals and 0.07ug/g in sugars. Fluoride in beverages showed the mean value of 0.46ug/g and fluoriide concentration in drinking water assumed the level of 0.1mg/1 in non fluoridated area in Japan. In calculation based on food intakes of recommendation in standard tables of food composition in Japan. The estimated mean DFIs for infant 3-8months of age were renged from 0.166-0.266mg/day and mean DFIs in 1-6 years olds were showed values of 0.289-0.321mg/day. DFIs por body weight ranged from 0.023-0..29mg/kg in infant of 3-8months of age and from 0.027-0.011mg/kg in 1-6years of age, that wore further lower levels than 0.05, 0.07mg/kg which is temperarily the criteria of the occurrence of onamel fluorosis (Food ＆ Nutrition Board, Institution of Medicine-National Academy of Sciences, USA). These results indicated that effectiveness and safety of fluoride applications should be available with on the estimation of AI (adequate intake) of fluoride in regional guidelines for defferent fluoride concentrations in drinking water. Less

为了确定个人每日氟化物摄入量的标准，必须进行氟化物分析，以确定世界范围内可获得的足够的氟化物摄入量。这些数据是为了监测氟化物的摄入量，以应用氟化物预防龋齿和口腔疾病。本研究的目的是估计婴儿配方奶粉、婴儿食品和市售日常食品的食品样品的DFIs。采用六甲基二硅氧烷（HMDS）微扩散法测定氟化物，温度60℃，时间12hr以上。在含氟0.1ppm的饮用水中，即食婴儿配方奶粉的氟化物浓度为0.14 ~ 0.22ug/ml（平均0.17ug/ml, h=10），作为婴儿食品的椰粕、肉鱼、蔬菜和果汁的氟化物含量平均值分别为0.30 （n=11）、0.13（n=20）、0.17 （n=11）和0.10ug/g （n=6）。另一方面，各食物组的平均氟化物浓度为：牛奶0.05ug/g，鸡蛋0.08ug/g，鱼和肉0.023ug /g，蔬菜0.06ug/g，土豆和淀粉0.02ug/g，水果0.07ug/g，谷物0.14ug/g，糖0.07ug/g。饮料中氟的平均值为0.46ug/g，日本非氟化地区的饮用水中氟的浓度假定为0.1mg/1。根据日本食品成分标准表中推荐的食物摄入量进行计算。3-8月龄婴儿的估计平均dfi从0.166-0.266mg/天下降，1-6岁婴儿的平均dfi为0.289-0.321mg/天。dfi的体重差范围为0.023-0..3-8个月的婴儿为29毫克/公斤，1-6岁为0.027-0.011毫克/公斤，这一水平进一步低于0.05、0.07毫克/公斤，这是发生氟斑牙症的临时标准（美国国家科学院医学研究所食品与营养委员会）。这些结果表明，氟化物应用的有效性和安全性应与饮用水中不同氟化物浓度的区域准则中对氟的适当摄入量的估计有关。少

项目成果

古賀 寛, 眞木吉信, 松久保隆, 高江洲義矩: "1歳-9歳児までの一日フッ化物摂取量(DFIs)の評価試案"口腔衛生学会雑誌. 51. 532-533 (2001)

Hiroshi Koga、Yoshinobu Maki、Takashi Matsukubo、Yoshinori Takaesu：“1 至 9 岁儿童每日氟化物摄入量 (DFI) 评估草案”口腔卫生学会杂志 51. 532-533 (2001)。

友利隆俊, 古賀 寛, 眞木吉信, 高江洲義矩: "乳児用食品中フッ化物分析と一日フッ化物摂取量の推定"口腔衛生学会雑誌. 51(2). 151-167 (2001)

Takatoshi Tomori、Hiroshi Koga、Yoshinobu Maki、Yoshinori Takaesu：“婴儿食品中氟化物的分析和每日氟化物摄入量的估计”口腔卫生学会杂志 51（2）。

H.koga etc: "A trial estimation of daily fluoride in Japan"47^<th> Annual meeting of the JADR, Program & abstracts papers. 119 (1999)

H.koga 等：“日本每日氟化物的试验估算”第 47 届 JADR 年会，计划

Koga, H., Maki, Y., Matsukubo, T., Takaesu, Y.: "Fluoride uptake to root surface with fluoride mouthrinses in vitro"Cariology Today. 2. 37-48 (2001)

Koga, H.、Maki, Y.、Matsukubo, T.、Takaesu, Y.：“体外含氟漱口水对根部表面的氟化物吸收”《今日龋齿学》。

"Fluoride Analysis for Infant food and Estimatin of Daily Fluoride Intakes"J Dent Hlth. 51. 156-167 (2001)

“婴儿食品的氟化物分析和每日氟化物摄入量的估算”J Dent Hlth。