FLUORIDE ANALYSIS IN INFANT FOODS AND ESTIMATION OF DAILY FLUORIDE INTAKES

婴儿食品中的氟化物分析和每日氟化物摄入量的估算

• 批准号: 08672388
• 负责人: KOGA Hiroshi
• 金额: $ 1.22万
• 依托单位: TOKYO DENTAL COLLEGE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672388/
• 关键词: caries prevention; fluoride analysis; daily fluoride intake; fluorede application; infant foods; microdiffusion; bioavailability; fluoride dissolution; フッ化物; 食品; フッ化物分析; 沖縄; 乳幼児用食品; ベビ-フード; フッ化物(F); loosely bound; tightly bound; Bioavaila

The Purpose of this study was to analyze the fluoride content in commercial infant foods and estimate of daily fluoride intake (DEl) during 3 -9 months old. Also the bioavailability of fluoride in human body is key factor to ascertain locally and systemically the effect of fluoride applications for the prevention of oral diseases. The bioavailability in foods is considered to depend on its ionization, bound form and its relationship to coexisting components. The other purpose of this study was to examine acid dissolution and ionization of fluoride in terms of bioavalability with some minerals contained in various foods. Ten kinds of powdered milk and 39 kinds of other infant foods were collected for determination of fluoride. HMDS-microdiffusion method (Koga et a1, 1994) was used to separate fluoride from infant foods. The dissolution of fluoride was performed with distilled water and 0.O1M HCI and 0.1M HCl. The samples were used of some high fluoride foods. Fluoride content found infa … More nts formula were ranged from 0.37-1.Oppm(mean fluoride content : 0.595 ppm) and other infant foods were ranged from 0.l0ppm to O.30ppm ready-to-feed fluoride content. Daily fluoride intake of infants estimates 0.175, 00.201 and 0.266mg/day for 3-4months, 5-6 months and 7-8months old, respectively. Daily fluoride intake of infants per kg was ranged 0.024-0.029mg/kg for 3-9 months old. This result indicate that daily fluoride intake from commercial infant foods could be within optimal fluoride level of 0.O7mgF/kg in Ophaug paper(1985) reported. Fluoride in infant foods investigated in this study had low concentrations of 0.21-2.9lppm and their fluoride dissolution rates were ranged from 25.4 to 74.7% with 0.O1M HCl. Fluoride in Antarctic Krill muscle might be loosely bound because of its high ionization with water and highly associated with the concentration of magnesium and the magnesium dissolution was very similar to that of fluoride with pH2-7 buffers. Fluoride dissolution rates of green tea (coarse grade) showed approximately 60% with water and 45% with 0.1M HCl, respectively. Therefore the results reflected that fluoride of green tea may exist both loosely and tightly bound. Bone meal and dried sardines contained higher calcium concentrations compared with other foods. As fluoride and calcium dissolutions of dried sardines and bone meal were strongly pH-dependent, it indicated that fluoride in their samples was presumed tightly bound to calcium. The results suggested that the bioavailability of fluoride be much influenced by the contents of magnesium in comparison with calcium with regard to ionization of fluoride in foods. Less

本研究旨在分析市售婴儿食品中氟含量，并估算3 ~ 9个月婴儿每日氟摄入量。此外，氟化物在人体内的生物利用度是确定局部和全身应用氟化物预防口腔疾病效果的关键因素。食品中的生物利用度被认为取决于其电离、结合形式及其与共存组分的关系。本研究的另一个目的是考察各种食物中所含的某些矿物质对氟化物的酸溶和电离作用的生物利用率。对10种奶粉和39种其它婴幼儿食品进行了氟含量测定。HMDS-微扩散法（古贺et a1，1994）用于从婴儿食品中分离氟化物。用蒸馏水和0.01M HCl和0.1M HCl进行氟化物的溶解。所用样品为高氟食品。氟含量测定 ...更多信息 婴儿配方食品的氟含量为0.37- 1.0ppm（平均氟含量为0.595ppm），其它婴儿食品的氟含量为0.10 - 0.30ppm。3- 4个月、5-6个月和7- 8个月婴儿每日摄氟量分别为0.175、00.201和0.266mg/d。3-9月龄婴儿每日摄氟量为0.024-0.029mg/kg/kg。这一结果表明，从商业婴儿食品中每日氟摄入量可以在Ophaug论文（1985）报道的最佳氟水平0.07mgF/kg范围内。本研究所调查的婴幼儿食品中氟的浓度较低，为0.21- 2.91ppm，在0.01M盐酸中氟的溶出率为25.4 - 74.7%。南极磷虾肌肉中的氟可能是松散结合的，这是由于其与水的高度电离以及与镁浓度的高度相关性，并且镁的溶解与pH 2 -7缓冲液中的氟非常相似。绿色茶（粗级）的氟溶解率分别显示约60%与水和45%与0.1M盐酸。因此，本研究结果反映了绿色茶中氟可能以松散和紧密结合的形式存在。与其他食物相比，骨粉和干沙丁鱼含有更高的钙浓度。由于干沙丁鱼和骨粉中氟和钙的溶出具有强烈的pH依赖性，这表明它们样品中的氟与钙紧密结合。结果表明，镁含量对氟的生物利用率影响较大，而钙含量对氟的电离作用较小。少

项目成果

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H.Koga 等：“血浆和唾液中蛋白质组分的氟化物分析”JADR 论文摘要（第 45 届年会，德岛）82 (1997)。

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Hiroshi Koga 等人：“根据市售婴儿食品中的氟化物估算的每日氟化物摄入量”《牙科杂志》96・3（1996 年）。