Synthesis and antioxidant activity of vitamin C analogs and vitamin E analogs

点击翻译按钮获取中文摘要

Reactive oxygen species (ROS) and free radicals induce oxidative stress and play the important role in developing and/or progression of human diseases such as cancer. So, antioxidants are expected to be a good lead compounds for medicines. In this study, we developed excellent antioxidants based vitamin C and E.1. Vitamin E analogsWe designed and synthesized benzo[h]chroman compounds (BC) which had benzene ring fused with vitamin E skelton and examined superoxide and OH radical quenching activity by ESR spin-trapping methods. Both activities were higher than that of trolox, which is vitamin E water-soluble analog.2. Vitamin C analogsReductic acid (RA) which has a 2,3-enediol moiety conjugated with a carbonyl group in a five-membered carbon ring was synthesized. RA inhibited xanthine oxidase activity, while ascorbic acid did not.RA quenched free radicals and also decreases active oxygen production. RA is thought to be a more potent inhibitor of active oxygen toxicity than ascorbic acid.Xanthine oxidase produces uric acid, which plays a crucial role in goat. Therefore, xanthine oxidase inhibitor works as a medicine for goat. RA is thought to be a promising inhibitor for oxidative stress and remedy for goat.Our data showed that BC and RA serves as a new starting structure for the design of pharmacologically effective compounds such as cancer.