Analysis of the phenolic antioxidants, some food additives, and chemicals found in plastic tableware which are suspected of being endocrine disruptors.

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Titles of two major papers and their abstracts are as follows.(1) Title : Simultaneous Determination of Sodium Benzoate and p-Hydroxybenzoate Esters Using High-performance Capillary Electrophoresis. Abstract : A rapid and simple capillary zone electrophoresis (CZE) method was developed for the simultaneous determination of sodium benzoate, potassium sorbate, sodium dehydroacetate, and the parabens, i. e. ethyl, n-propyl, and n-butyl p-hydroxybenzoic esters, which are used in several processed foods as preservatives. The compounds were well separated from each other on a fused silica capillary utilizing a 20 mM sodium tetraborate buffer and UV detection at 200 nm. The total analysis time was less than seven minutes per sample. Concentrations of sodium benzoate and n-butyl paraben in several soft drinks were determined using the CZE method and the levels of sodium benzoate and n-butyl paraben in the samples were in good agreement with those determined by the HPLC procedure.(2) Title : Co … More mparison Among High-performance Liquid Chromatography, High-performance Capillary Electrophoresis and Gas Chromatography for the Simultaneous Determination of Phenolic Antioxidante. Abstract : Two major phenolic antioxidant food additives, 2-and 3-tert-4-hydroxyanisole (BHA) and 3, 5-di-tert-butyl-hydtroxytoluene (BHT), were determined in standard solutions using HPLC with an electrochemical detector, micellar electrokinetic capillary electrophoresis (MEKC) and capillary gas chromatography (GC). Analysis time was 22 minutes by HPLC-ECD and ten minutes by both MEKC and GC. Calibration curves obtained by comparing peak areas against concentrations showed a high degree of linearity (R^2>0.99) in all three methods. Of the three methods, BHA and BHT were detectable in the smallest amounts (10^<-14>moles) by MEKC. Variation in retention or migration time was ≦1.0% (R. S. D., %) on any given day, but was slightly higher than 1.0% by MEKC on separate days. Repeatability in peak-area also varied by ≦5.0% for both HPLC-ECD and GC, but varied by ≧5.0% for MEKC. Intermediate precision in peak-height of the antioxidants varied by ≦5.0% for MEKC. These methods were found to be suitable for the simultaneous determination of BHA and BHT concentrations in foods. Less