The development of materials for foods and drugs by bio-power of marine microorganisms

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We constructed a marine microorganism library to find the bacteria that produce materials useful for developing new foods or drugs. This microorganism library provides us the following new results. First, we found two strains of marine bacteria showing the ability to inhibit melanogenesis that is comparable to that of 0. 25 mM ascorbic acid by screening 548 strains of marine bacteria. The bacteria-secreted inhibitors are heat-resistant and show no reductive activity. Then, we also found 24 strains of marine bacteria showing the ability to inhibit the growth of colon cancer cells by screening 2,480 strains of marine bacteria. In addition, we found that mannuronate polymer, one of components of alginate, suppressed the motility of glioblastoma cells having wild-type p53 gene after X-irradiation. Furthermore, we found that galacturonic acid stimulated Chattonella marina and Heterosigna akashiwo to generate increased amounts of O_2-, suggesting that the binding of galacturonic acid to specific sites on the flagellate cell surface may induce the increase of O_2- production. Finally, we established in vitro and in vivo screening systems that were hypersensitive to detect endocrine desruptors in the marine resources.