Evaluation of the radiation effect on selective chromosome segregation in stem cells
Evaluation of the radiation effect on selective chromosome segregation in stem cells
批准号:
23310039
负责人:
KODAMA Seiji
金额:
$12.65万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
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英文摘要
We studied an effect of radiation on selective chromosome segregation and the relationship between the number of cells showing selective chromosome segregation and p53 expression in mouse neurosphere cells. The result revealed that the number of cells showing selective chromosome segregation was reduced depending on irradiated X-ray doses. This reduction may be related to the dose-dependent decrease in number of CD133 positive cells. In addition, the cells showing selective chromosome segregation were not observed in p53 knock out (KO) mouse neurosphere cells and the number of those cells was significantly reduced in p53 knock down (KD) neurosphere cells, suggesting that the p53 function is involved in the regulation of selective chromosome segregation.
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Increased susceptibility to delayed genetic effects of low dose X-irradiation in DNA repair deficient cells
DNA 修复缺陷细胞对低剂量 X 射线照射延迟遗传效应的敏感性增加
DOI:
10.3109/09553002.2013.752596
发表时间:
2013
期刊:
Int J Radiat Biol.
影响因子:
--
作者:
[Kashino G, Suzuki K, Kodama S, Watanabe M, Prise KM]
通讯作者:
Prise KM
神経幹細胞に蓄積する放射線損傷の影響
辐射损伤累积对神经干细胞的影响
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Tomoya Nakahama, Kazunori Shiraishi, Seiji Kodama, 白石一乗,山村直己,柏木裕呂樹,福井真希,坂口健太,児玉靖司]
通讯作者:
白石一乗,山村直己,柏木裕呂樹,福井真希,坂口健太,児玉靖司
UV-A照射染色体の移入による遺伝的不安定性の誘発
UV-A 照射染色体转移诱导遗传不稳定性
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Li J., Shimizu K., Maseda H., Lu Z., Utsumi M., Zhang Z., and Sugiura N, 小野純, 高橋昭久, 漆原あゆみ]
通讯作者:
漆原あゆみ
Induction of a whole chromosome loss by colcemid in human cells elucidated by discrimination between FISH signal overlap and chromosome loss
通过区分 FISH 信号重叠和染色体丢失来阐明秋水酰胺在人类细胞中诱导整个染色体丢失
DOI:
10.1016/j.mrfmmm.2013.06.001
发表时间:
2013
期刊:
Mutation Research
影响因子:
--
作者:
[Yamamoto, M., Wakata, A., Aoki, Y., Miyamae, Y., and Kodama, S.]
通讯作者:
S.
医療関係者に求められる放射線の人体影響に関する説明
要求医务人员解释辐射对人体的影响
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Tomoya Nakahama, Kazunori Shiraishi, Seiji Kodama, 白石一乗,山村直己,柏木裕呂樹,福井真希,坂口健太,児玉靖司, 児玉靖司]
通讯作者:
児玉靖司
共 26 条
A mechanism for the reduced DNA damage in mice irradiated in fetuses and newborns
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批准号:26550032
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2014
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负责人:KODAMA Seiji
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依托单位:
A mechanism for chromosome instability mediated by micronuclei induced with radiation
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批准号:26281024
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.4万
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财政年份:2014
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负责人:KODAMA Seiji
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依托单位:
The mechanism for delayed chromosome rearrangements mediated by radiation-induced telomere instability
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批准号:24651051
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.58万
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财政年份:2012
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负责人:KODAMA Seiji
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依托单位:
Establishment of an assay system for biological effect of radiation using neural stem cells
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批准号:22651019
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.23万
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财政年份:2010
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负责人:KODAMA Seiji
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依托单位:
Memory and transmission of genomic instability induced by ionizing
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批准号:18310040
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.51万
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财政年份:2006
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负责人:KODAMA Seiji
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依托单位:
The study on genomic instability initiated by radiation signature using the chromosome transfer techniue
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批准号:15310040
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.4万
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财政年份:2003
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负责人:KODAMA Seiji
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依托单位:
Involvement of telonomic instability in induction of delayed chromosome aberrations by ionizing radiation
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批准号:11680552
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
-
财政年份:1999
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负责人:KODAMA Seiji
-
依托单位:
The development of materials for foods and drugs by bio-power of marine microorganisms
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批准号:11794013
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项目类别:Grant-in-Aid for University and Society Collaboration
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资助金额:$8.32万
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财政年份:1999
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负责人:KODAMA Seiji
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依托单位:
Mechanism of cell cycle checkpoint in the cells transfected with sense or antisense gadd45 gene
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批准号:07680585
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
-
财政年份:1995
-
负责人:KODAMA Seiji
-
依托单位:
海外基金