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Principle of diversity, differentiation, and stability in biological systems

生物系统的多样性、分化和稳定性原理

基本信息

批准号：
11837004
负责人：
KANEKO Kunihiko
金额：
$ 2.5万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

项目摘要

We have searched for universal logic of a life systemin terms of dynamical systems, while characteristics of novel dynamical systems to support life systems have also been studied.(1) Cell differentiation : Earlier we have shown that robust development and cell differentiation are universal outcome in a prototype cell system with reaction networks, cell-cell interaction through diffusion, and reproduction. The reaction network allowing for chaotic dynamics is generally shown to support such differentiation, and that such cell system is found to have a higher growth rate as a cell ensemble, by achieving cooperation. Such system exhibits irreversible differentiation process from totipotency to determination, which is characterized by the decrease of chemical diversity and dynamic plasticity.(2) Extending the above model to include spatially local interaction, spontaneousgeneration of positional information is found, which supports robust morphogenesis.(3) Considering a system of mutually … More catalyzing molecules, spontaneous formation of a molecule working as information carrier is demonstrated, that leads to the origin of information in a cell.(4) In a system with small number of molecules, a novel phase that was not treated by continuum description is discovered, which can be related with signaling dynamics in a cell.(5) Theory of robust sympatric speciation is proposed by theisologous diversification mechanism.(6) In coupled dynamical systems with a variety of time scales, a mechanism in which faster elements influence slower elements is discovered.(7) In a class of Hamiltonian dynamics with a large degree of freedoms, it is shown that energy can be stored over long time, which increases exponentially with the stored energy, while the time is shown tobe inversely proportional to residual Kolomogorov-Sinai entropy. Connection with energy transduction in molecular motor is also discussed.(8) Dynamical systemsgame theory, function dynamics as an abstract cognition system, and dynamical systems feature of computation process have also been studied Less

我们从动力系统的角度寻找生命系统的普适逻辑，同时也研究了支持生命系统的新动力系统的特征。(1)细胞分化：早些时候，我们已经表明，强大的发展和细胞分化是具有反应网络的原型细胞系统中的普遍结果，通过扩散和繁殖的细胞-细胞相互作用。允许混沌动力学的反应网络通常被示出支持这种分化，并且发现这种细胞系统通过实现合作作为细胞系综具有更高的生长速率。这类系统表现出从全能性到决定性的不可逆分化过程，其特征是化学多样性的降低和动态可塑性。(2)扩展上述模型，包括空间局部相互作用，发现位置信息的自发生成，这支持强大的形态发生。(3)考虑到一个相互 ...更多信息催化分子，作为信息载体的分子的自发形成被证明，导致细胞中的信息的起源。(4)在小分子系统中，发现了一个未被连续统描述的新相，它可能与细胞中的信号动力学有关。(5)根据物种多样性机制，提出了稳健同域物种形成理论。(6)在具有多种时间尺度的耦合动力系统中，发现了一种快元素影响慢元素的机制。(7)在一类具有大自由度的Hamilton动力学中，能量可以在很长的时间内储存，并随储存的能量呈指数增长，而时间与剩余Kolomogorov-Sinai熵成反比.讨论了分子马达中能量转换的关系。(8)动力系统博弈论、作为抽象认知系统的函数动力学以及计算过程的动力系统特征也得到了研究