Effect of Environmental Endocrine Disrupters on pancreatic hormones secretion

点击翻译按钮获取中文摘要

We pay attention Environmental Endocrine Disrupters (EEDs).Some of them have the actions like estrogen. Estrogen is important for development or propagation. It has many other actions ; lipid metabolism, bone metabolism and so on, but it is not clear whether estrogen has any action on pancreatic hormone secretion. On the other hand patients with diabetes mellitus increase rapidly in Japan. We make a hypothesis that EEDs may any relation with the increase of diabetes mellitus.So to clarify whether some of EEDs have any effect on insulin secretion we studied the effects of Bisphenol A and Nonylphenol by using rat isolated pancreatic islets.Our data suggest that the pancreatic islets have the estrogen receptor (α type and β type). We also suggest that Bisphenol A and Nonylphenol have the insulinotropic actions using isolated pancreatic islets examinations.