New viewpoint for prevention of life style-related diseases-verification of thrifty phenotype hypothesis

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To clarify the relationships between birth weight and life style related diseases, we examined medical examination. The subjects are two groups. We got birth weights by their maternity health record books. In 243 Japanese healthy high school girls the association of low birth weight could be detected to be significant with such risks of metabolic syndrome as SBP, DBP, TG, insulin level and insulin resistance indicating the importance of follow-up study and food education program for the prevention of MS in the later life. In middle aged group medical examination the relationship between the birth weight and present BMI shows U curve. The ratio of fasting plasma glucose levels over 100mg/dl is high in low birth weight group. These data show that low birth weight is high risk for life style-related diseases in later life.