Metabolite regulation of mitochondrial fission

线粒体裂变的代谢调节

• 批准号: DP220103700
• 负责人: A/Prof Jonathan Oakhill
• 金额: $ 39.87万
• 依托单位: Australian Catholic University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-10-06 至 2025-10-05
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103700
• 关键词: Metabolite; regulation; mitochondrial; fission

This project aims to understand how the function and health of mitochondria – the energy producing structures in cells - are controlled by fat molecules. The project expects to integrate cutting edge techniques and instrumentation to generate new knowledge of how fat molecules interact with, and influence, enzymes that control how cells maintain their mitochondria in response to nutrient state. An anticipated goal is to define a fingerprint for enzymes regulated by fat molecules that will be of great interest to researchers across many branches of life sciences. Expected outcomes and benefits will be deeper understanding of fat molecules as nutrient signalling metabolites, and how they influence cell metabolism, growth and development.

该项目旨在了解线粒体的功能和健康-细胞中的能量产生结构-如何由脂肪分子控制。该项目预计将整合尖端技术和仪器，以产生关于脂肪分子如何与酶相互作用并影响酶的新知识，这些酶控制细胞如何维持线粒体以响应营养状态。一个预期的目标是定义由脂肪分子调节的酶的指纹，这将是生命科学许多分支的研究人员非常感兴趣的。预期的成果和益处将是更深入地了解脂肪分子作为营养信号代谢物，以及它们如何影响细胞代谢，生长和发育。