Microbiome Regulation of the Host Mitochondrial Genome

该项目旨在描述新发现的过程，通过这些过程，驻留在动物肠道中的细菌影响宿主线粒体，细胞的动力。利用先进的遗传和分子方法，该项目旨在产生关于改善线粒体功能的新知识，并促进我们对微生物组研究新兴领域的理解。预期结果包括一个新颖和通用的技术平台，其中设计小分子和益生菌，以改善线粒体健康和增强一系列动物的健康。通过科学相关的成果和技术进步带来的经济效益，这将带来显著的效益。

This project aims to describe newly discovered processes by which bacteria that reside in the gut of an animal influences host mitochondria, the powerhouses of the cell. Using advanced genetic and molecular methodologies, this project aims to generate new knowledge on improving mitochondrial function as well as advance our understanding of the emerging field of microbiome research. Expected outcomes include a novel and universal technology platform in which to engineer small molecules and probiotics to improve mitochondrial health and enhance fitness in a range of animals. This should provide significant benefits, through both scientifically relevant outcomes and economic benefits through technological advancements.