权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The real dynamics of mental function in the brain -A pilot study for the hypothesis of working memory by using the spectropic topography-.

大脑中心理功能的真实动态 - 使用光谱地形图对工作记忆假设进行初步研究 -。

基本信息

批准号：
11680391
负责人：
KOMORI Kenjiro
金额：
$ 2.37万
依托单位：
Ehime University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

项目摘要

Degradation of higher brain functions is reflected in patients' behavior. We investigated the two types of degenerative dementia, one is fronto-temporal lobar degeneration (FTLD), which is a representative of the anterior type of dementia, and the other is Alzheimer's disease (AD), which is a representative of the posterior type of dementia. In this study we tried to solve the functional enigmas of frontal lobe in which working memory is mainly mediated. In cases of fronto-temporal dementia with principle involvement of the frontal lobe, clinical data revealed preservation of procedural skills and other implicit memory, while in cases of semantic dementia with principle involvement of the temporal lobes, procedural skills were preserved, but priming that underlies semantic system was impaired. 'Going my way' behavior is one of the most prominent symptoms of FTLD.This behavior can be interpreted as a loss of control of the frontal lobe over the limbic system. We proposed appropriate utilization of this behavior for the care of patients with FTLD.In 90 AD patients, we assessed hemokinetics associated with changes in severity of dementia using Alzheimer's Disease Assessment Scale (ADAS), which can assess precise cognitive dysfunction in AD.The results revealed the following mechanism for blood flow kinetics associated with changed severity : In an early stage of AD, blood flow in the medial temporal cortex is impaired, and the temporoparietal regions are gradually involved. While the medial temporal impairment of blood flow reaches a plateau, temporoparietal blood flow continues to be impaired well into a severe stage, at which point blood flow impairment in the frontal region is initiated.

高级大脑功能的退化反映在患者的行为上。我们调查了两种类型的退行性痴呆，一种是额颞叶变性（FTLD），这是前型痴呆的代表，另一种是阿尔茨海默病（AD），这是后型痴呆的代表。本研究试图解开额叶的功能之谜，工作记忆在额叶中起着重要的中介作用。在额颞叶痴呆与额叶的原则参与的情况下，临床数据显示程序技能和其他内隐记忆的保存，而在语义性痴呆与颞叶的原则参与的情况下，程序技能被保存，但启动语义系统受损。“我行我素”行为是FTLD最突出的症状之一，这种行为可以解释为额叶对边缘系统失去控制。我们建议适当利用这种行为来照顾FTLD患者。在90例AD患者中，我们使用阿尔茨海默病评估量表（ADAS）评估与痴呆严重程度变化相关的血流动力学，该量表可以评估AD的精确认知功能障碍。结果显示，与严重程度变化相关的血流动力学机制如下：在AD的早期阶段，内侧颞叶皮质的血流受损，并且逐渐累及颞顶区域。虽然内侧颞部血流受损达到平台期，但颞顶血流继续受损至严重阶段，此时额叶区域的血流受损开始。