Development of artificial skin containing biological active substance with wound healing potency

本研究旨在研制一种新的含有生物活性物质的人工皮肤，用于治疗烧伤和慢性皮肤溃疡。用含双丁酰环磷酸腺苷的透明质酸海绵制成的人工皮肤，在动物实验中对大鼠创面愈合有很好的效果。此外，作者还关注了成纤维细胞的潜能。这些细胞能够释放促进血管形成所必需的血管内皮生长因子。由成纤维细胞结合透明质酸和胶原蛋白的双层海绵基质组成的人工皮肤在临床试验中被证明对伤口愈合非常有效。通过这项研究，开发了两种类型的人工皮肤。一种是含有生物活性物质的人造皮肤。另一种是含有能够释放生物活性物质的成纤维细胞的人造皮肤。

This study was designed to develop a new artificial skin containing biological active substance acceptable for the treatment of burn injury and chronic skin ulcer. The artificial skin composed of hyaluronic acid spongy containing dibutyryl cyclic AMP was proved very effective in wound healing in animal tests using rats. In addition, the authors focused on the potency of fibroblasts. These cells are able to release vascular endothelial growth factor which is necessary for promoting vasculalization. The artificial skin composed of fibroblasts combined with a two-layered spongy matrix of hyaluronic acid and collagen was proved very effective in wound healing in clinical trials. Through this study, two types of artificial skins were developed. One is an artificial skin containing biological active substance. Another is an artificial skin containing fibroblasts which are able to release biological active substances.