Advanced Chemical Protein Synthesis and Applications

该项目旨在开发增强的多肽、寡核苷酸和蛋白质的化学组装方法。这将导致在化学和结构生物学方面创造新的知识，并为药物发现过程、药物制造和生物催化方面的进展奠定基础。一旦完成，预计将接踵而至的是更低成本、更环保的药物制造工艺，如恩福韦肽(用于艾滋病毒)。还将开发新一代超稳定、环境友好的催化剂。这可能使国内能够生产精细化学品和基本药物，从而在一个更多元化、更具弹性的经济中创造高科技就业机会。最终，它可能会改善人类健康的结果。

This project aims to develop enhanced methods for the chemical assembly of peptides, oligonucleotides and proteins. This will lead to the creation of new knowledge in chemistry and structural biology, and underpin advances in the drug discovery process, pharmaceutical manufacture and biocatalysis. Once complete, it is expected that lower cost, greener processes for manufacturing drugs such as Enfuvirtide (for HIV) will ensue. A new generation of hyper-stable, environmentally friendly catalysts will also be developed. This could enable domestic production of fine chemicals and essential medicines, and thus create high-tech jobs in a more diversified, resilient economy. Ultimately, it could lead to improved outcomes in human health.