Multiscale mathematical modelling to gain insights into hepatitis viruses

多尺度数学建模以深入了解肝炎病毒

• 批准号: DE220100284
• 负责人: Dr ASHISH GOYAL
• 金额: --
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-10-01 至 2023-10-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220100284
• 关键词: Multiscale; mathematical; modelling; gain; insights

This project aims to use mathematical modelling to study hepatitis viruses at multiple levels. The project expects to develop complex yet analysable mathematical models to comprehend the fundamental biology of hepatitis viruses by elucidating longitudinal patterns in viral and immune markers at intracellular and cellular levels, and advance a new subfield in mathematical biology, i.e., modelling codependent human viruses. Expected outcomes of the project include new generalized mathematical tools, biological insights that may aid research beyond the scope of this project, and strong interdisciplinary collaborations. Expected benefits include an increased capacity of the research community in Australia to use mathematical models in virology.

该项目旨在利用数学建模在多个层面上研究肝炎病毒。该项目预计将开发复杂但可分析的数学模型，通过阐明细胞内和细胞水平上病毒和免疫标志物的纵向模式来理解肝炎病毒的基本生物学，并推进数学生物学的一个新的子领域，即，模拟相互依赖的人类病毒。该项目的预期成果包括新的通用数学工具，可能有助于本项目范围以外的研究的生物学见解，以及强大的跨学科合作。预期的好处包括提高澳大利亚研究界在病毒学中使用数学模型的能力。