Interrogating the adaptive potential of skeletal muscle

探究骨骼肌的适应潜力

• 批准号: DE220100259
• 负责人: Dr Justin Hardee
• 金额: $ 33.66万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-05-23 至 2025-05-22
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220100259
• 关键词: Interrogating; adaptive; potential; skeletal; muscle

Disruptions to muscle oxidative capacity and growth signalling underpin atrophy and dysfunction with ageing, which impacts on an individual’s quality of life. These biological processes are thought to be mutually exclusive and compete during muscle adaptation. This project aims to define how these processes regulate the extent of muscle adaptation, and how modifying these attributes influence functional capacity in the context of ageing. This project will provide fundamental new knowledge in understanding how modifying muscle attributes influence successful ageing. This knowledge will improve resilience, productivity, and wellbeing of all Australians, with implications for reducing societal and economic burden.

肌肉氧化能力和生长信号的破坏会导致衰老引起的萎缩和功能障碍，从而影响个人的生活质量。这些生物过程被认为是相互排斥的，并且在肌肉适应过程中相互竞争。该项目旨在定义这些过程如何调节肌肉适应的程度，以及修改这些属性如何影响衰老背景下的功能能力。该项目将提供基本的新知识，帮助理解改变肌肉属性如何影响成功的衰老。这些知识将提高所有澳大利亚人的复原力、生产力和福祉，对减轻社会和经济负担具有影响。