Decoding the evolution of killer T cell immunity across human lifetime

解码杀伤性T细胞免疫在人类一生中的进化

• 批准号: DE220100185
• 负责人: Dr Carolien van de Sandt
• 金额: $ 31.52万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220100185
• 关键词: Decoding; evolution; killer; cell; immunity

The immune system is a potent weapon for protection against pathogens. T cells have a central role as their receptors monitor the body for threats. The thymus (organ) educates receptors to discriminate between healthy and infected cells. Receptor diversity and T cell strength change throughout human life. This project aims to unravel how T cells gain and lose optimal receptors and strength. The aims are to understand 1) The role of thymic education in diversifying receptors 2) Whether gradual loss of thymic education affects receptor diversity 3) The molecular mechanisms underlying T cell strength. The project is essential for understanding how optimal T cell immunity is formed, critical if we wish to harness this to improve healthy aging.

免疫系统是抵御病原体的有力武器。T细胞的受体在监视身体的威胁方面起着核心作用。胸腺（器官）引导受体区分健康细胞和感染细胞。受体多样性和T细胞强度在人的一生中都会发生变化。该项目旨在揭示T细胞如何获得和失去最佳受体和强度。目的是了解1)胸腺教育在受体多样化中的作用2)胸腺教育的逐渐丧失是否会影响受体多样性3)T细胞强度的分子机制。这个项目对于理解最佳T细胞免疫是如何形成的至关重要，如果我们希望利用它来改善健康衰老，这一点至关重要。