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A sutdy for analyzing causative genes for common diseases in urinary tract and male sex organs

泌尿道及男性性器官常见疾病致病基因分析研究

基本信息

批准号：
12307034
负责人：
SHUIN Taro
金额：
$ 19.09万
依托单位：
Kochi Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12307034/
关键词：
common disease urinary tract caluculi BPH Infantile anomaly in male sex organ genitourinary cancer DNA microarray analyses microarray 尿路結石前立腺癌尿路上皮癌腎細胞癌精巣腫瘍多因子疾患遺伝子型腎尿路癌マイクロアレイ

项目摘要

there are a many common disease in the genitourinary tract organ. For example, urinary tract calculi (uric acid or, oxalic acid calcium calculi), BHP, the anormalies in infant urinary tract and in male sex organs, the genitourinary tract cancer, and male sterility are such kinds of disease. It is difficult to explain such kinds of diseases as single gene diseases such as recessive or dominant hereditary diseases. These are regarded as multifactor diseases. The causative genes in these diseases are not known yet. It is important for us to accumulate DNA from the organs or blood DNA in such patients. It is also essential to analyze single nucleotide polymorphism (SNP) of candidate gene from accumulated DNA. In the present study we selected some among such kinds of common disease and accumulated DNAs from such patients. We tried to collect the 300 DNAs from the diseases such as BPH, urine tract calculi, genitourinary tract cancer (prostatic cancer, urothelial cancer, kidney cancer, germ cell tumor), We also performed DNA microarray analyses with some study designs for such diseases in order to select candidate gene groups. If causative genes are detected and new idea for the treatment is elucidated in urinary tract calculi, BPH, urinary tract anormalv in infancy and male sex organs, the genitourinary tract cancer, future foundations for the urology are established and further advances for clinical diagnosis and treatment become possible.Blood DNAs are collected in patients with 150 of kidney cancers, 46 of germ cell tumnrs 273 of prostatic cancers, 276 of tumors in the urinary bladder, 141 of PBH, 129 of urine tract calculi, 28 of hypospadia, 9 of VUR, other 56 diseases, and 37 of normality person. Total number reachs to 1145 in this project. We were able to search some candidate genes in DNA microarray analyses in some study designs. Each members also performed a study with their own study project and got some result.

泌尿生殖道器官有许多常见病。如尿路结石（尿酸或草酸钙结石）、必和必拓、婴幼儿尿路及男性性器官异常、泌尿生殖道癌、男性不育症等。单基因疾病如隐性遗传病或显性遗传病很难解释。这些被认为是多因素疾病。这些疾病的致病基因尚不清楚。从这些病人的器官或血液中积累DNA对我们来说很重要。从积累的DNA中分析候选基因的单核苷酸多态性（SNP）也是必要的。在本研究中，我们从这些常见疾病中选择了一些，并从这些患者中积累了dna。我们试图收集来自前列腺增生、尿路结石、泌尿生殖系统癌（前列腺癌、尿路上皮癌、肾癌、生殖细胞瘤）等疾病的300个DNA，并对这些疾病的一些研究设计进行DNA微阵列分析，以选择候选基因群。如果能在尿路结石、BPH、婴幼儿尿路异常及男性性器官、泌尿生殖道癌中发现致病基因，阐明新的治疗思路，为今后泌尿外科奠定基础，进一步推进临床诊疗提供可能。收集了150例肾癌患者、46例生殖细胞瘤患者、273例前列腺癌患者、276例膀胱肿瘤患者、141例PBH患者、129例尿路结石患者、28例尿道下裂患者、9例VUR患者及其他56例疾病患者、37例正常人的血液dna。本项目总数量达到1145人。在一些研究设计中，我们能够在DNA微阵列分析中搜索一些候选基因。每个成员还对自己的研究项目进行了研究，并取得了一些成果。