Clinical development of early detection method for renal cell carcinoma with serum cancer markers and methylated DNA-fragment cancer markers
Clinical development of early detection method for renal cell carcinoma with serum cancer markers and methylated DNA-fragment cancer markers
批准号:
19390417
负责人:
SHUIN Taro
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
ヒト腎の問題点は診断マーカーが存在しないため画像以外には早期診断が難しいこと、また転移の早期発見が難しく転移癌への有効な治療法が存在しないことである。そのためヒトDNAメチル化マーカーと血清マーカーの開発を検討した。その結果血清マーカーHIG2, TMEM22などの有用性を検討し明らかにした。またmethylated DAN marker HOXb13などを中心にメチル化DNAマーカーについても蛋白の発現誘導実験を行い、新しいマーカーの存在を検討した。
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Renal leiomyoma : an immunohistochemical, ultrastructural and comparative genomic hybridizion study Histol Histopathol
肾平滑肌瘤:免疫组织化学、超微结构和比较基因组杂交研究 Histol Histopathol
DOI:
--
发表时间:
2007
期刊:
22(8)
影响因子:
--
作者:
[Kuroda N, Inoue Y, Taguchi T, Tominaga A, Hes O, Michal M, Hayashi Y, Hiroi M, Shuin T, Lee GH.]
通讯作者:
Lee GH.
DOI:
10.1158/1078-0432.ccr-06-2766
发表时间:
2007-06-15
期刊:
CLINICAL CANCER RESEARCH
影响因子:
11.5
作者:
[Daibata, Masanori, Nemoto, Yuiko, Taguchi, Hirokuni]
通讯作者:
Taguchi, Hirokuni
Blockade of the vascular endothelial growth factor-receptor 2 pathway inhibits the growth of human renal cell carcinoma, RBM1-IT4, in the kidney but not in the bone of nude mice.
阻断血管内皮生长因子-受体 2 通路可抑制人肾细胞癌 RBM1-IT4 在肾脏中的生长,但不会在裸鼠的骨骼中生长。
DOI:
--
发表时间:
2007
期刊:
Int J Oncol 30(4)
影响因子:
--
作者:
[浅野桐子, 高沢亮治, 木原和徳, Touko Asano, 浅野桐子, 高沢亮治, Karashima T]
通讯作者:
Karashima T
Chromophobe renal cell carcinoma: useful diagnostic application imprinttology and fluorescence in situ hybridization of chromosomes 10 and 21 in two cases of typical and eosinophilic variants
嫌色肾细胞癌:在两例典型变异和嗜酸性变异中,10 号和 21 号染色体的印迹学和荧光原位杂交的有用诊断应用
DOI:
--
发表时间:
2008
期刊:
MedMolMorphol 41(4)
影响因子:
--
作者:
[Kuroda N, Katto K, Yamaguchi T, KaT, Imamura Y, Hes O, Michal M, Shuin T, Lee GH.]
通讯作者:
Lee GH.
KTernary complex formation of pVHL, elongin B and elongin C visualized in living cells by a fluorescence resonance energy transfer-fluorescence lifetime imaging microscopy technique
K 通过荧光共振能量转移-荧光寿命成像显微镜技术在活细胞中观察 pVHL、elongin B 和 elongin C 三元复合物的形成
DOI:
--
发表时间:
2007
期刊:
FEBS J. 274(21)
影响因子:
--
作者:
[Kinoshita K, Coryo K, Takada M, Tomokuni Y, Aso T, Okuda H, Shuin T, Fukumura H, Sogawa]
通讯作者:
Sogawa
共 13 条
Development of laminin-gamma2 monomer as a potent biomarker for upper urinary tract cancer
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批准号:17K11144
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2017
-
负责人:SHUIN Taro
-
依托单位:
Basic Strategy for the treatment of kidney cancer : identification and clinical utilization of new tumor suppressor genes or oncogenes closely correlated with VHL gene VHL
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批准号:16390465
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.15万
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财政年份:2004
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负责人:SHUIN Taro
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依托单位:
Elucidation in the mechanism of human renal cell carcinoma cancer growth and micrometastasis with inactivation of VHL
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批准号:14370515
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.3万
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财政年份:2002
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负责人:SHUIN Taro
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依托单位:
A sutdy for analyzing causative genes for common diseases in urinary tract and male sex organs
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批准号:12307034
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$19.09万
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财政年份:2000
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负责人:SHUIN Taro
-
依托单位:
Molecular detection of kidney cancers with VHL gene mutation in the blood, urine or lymph node
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批准号:11557118
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.17万
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财政年份:1999
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负责人:SHUIN Taro
-
依托单位:
VHL tumor suppressor gene : Identification its function for cell growth inhibition and cell ular apoptosis for kidne cancer to develop new modality of treatment
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批准号:09470348
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.94万
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财政年份:1997
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负责人:SHUIN Taro
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依托单位:
In vitro expression of von Hippel-Lindau tumor suppressor gene in human renal cell carcinoma by Herpes simplex virus vector
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批准号:07557105
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.58万
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财政年份:1995
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负责人:SHUIN Taro
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依托单位:
Anew trial of Genetic dlagnosisand treatment of kidney cancer based on the abnormallty in the oncogene and tumor suppressor gene Head invastigator ; Registered invastigators : Resgistered
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批准号:05671330
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1993
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负责人:SHUIN Taro
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依托单位:
海外基金