Determining the regulation of ovary development with single cell sequencing

通过单细胞测序确定卵巢发育的调控

• 批准号: DE220100006
• 负责人: Dr Jessie Sutherland
• 金额: $ 27.61万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-12-31 至 2025-12-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220100006
• 关键词: Determining; regulation; ovary; development; single

This project will greatly advance our understanding of ovary development and mammalian reproduction. I will investigate the process of ovarian primordial follicle activation including its genetic regulation, the importance of supportive granulosa cells and the biological significance of regulatory factors. This will be achieved through the comprehensive investigation of a single cell transcriptomic dataset of ovarian development (Aim 1) in conjunction with functional studies (Aim 2). The outcomes of which will hold significant benefit to animal reproduction through new strategies to improve livestock productivity and control invasive pest species. These outcomes are of economic and environmental and benefit nationally.

该项目将极大地促进我们对卵巢发育和哺乳动物生殖的认识。我将探讨卵巢原始卵泡激活的过程，包括其遗传调控，支持颗粒细胞的重要性和调节因子的生物学意义。这将通过对卵巢发育单细胞转录组数据集（目标1）的综合研究以及功能研究（目标2）来实现。其结果将通过新的策略来提高牲畜生产力和控制入侵害虫，从而对动物繁殖产生重大益处。这些成果具有经济效益、环境效益和国家效益。