The role of primordial follicle activation in premature ovarian failure

原始卵泡激活在卵巢早衰中的作用

• 批准号: nhmrc : GNT1120481
• 负责人: Dr Jessie Sutherland
• 金额: $ 31.88万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-primordial-follicle-ovarian-failure/1347139
• 关键词: role; primordial; follicle; activation; premature

As women age, both the quality and quantity of their eggs decline and their chances of conceiving plummets. Premature ovarian failure (POF) is a disease of infertility, diagnosed in 3% of all women, defined by the early onset of menopause before age 40. Our poor understanding of the factors that regulate female egg supply remains a major limitation in treating POF. I will study key factors responsible for controlling egg number, with practical implications for POF diagnosis and treatment.

随着女性年龄的增长，卵子的质量和数量都会下降，怀孕的几率也会直线下降。卵巢早衰（POF）是一种不孕症，在所有女性中诊断为3%，定义为40岁前绝经的早期发作。我们对调节女性卵子供应的因素的理解不足仍然是治疗POF的主要限制。我将研究控制卵子数量的关键因素，对POF的诊断和治疗具有实际意义。