A Kinetic Study on the Mass Transfer Phenomena in Reversed-Phase Liquid Chromatography
反相液相色谱传质现象的动力学研究
基本信息
- 批准号:12640581
- 负责人:
- 金额:$ 2.24万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2000
- 资助国家:日本
- 起止时间:2000 至 2003
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Kinetic studies on the mass transfer phenomena in columns were studied by means of pulse response experiments and the moment analysis under the conditions of reversed-phase liquid chromatography (RPLC). Various stationary phases having different physical and chemical properties were used, that is, porous silica gel particles bonded with alkyl chains of different carbon numbers, porous silica gel particles bonded with C_<18>-ligands of different surface coverages, porous silica gel particles bonded with phenyl group, porous particles made of styrene-divinylbenzene copolymer, and porous particles made of graphitic carbon. Methanol/water mixtures and standard materials of benzene derivatives and phenol derivatives were mainly used as the mobile phases and sample compounds, respectively. The information about the retention equilibrium and mass transfer kinetics were derived from the first absolute moment and the second central moment of the elution peak profiles. Especially, the characteri … More stics and mechanism of surface diffusion were studied in detail. To the best of the author's knowledge, there is so far no systematic study on surface diffusion. Thermodynamic properties of the retention equilibrium and surface diffusion were derived from the results of the pulse response experiments carried out under different temperature conditions. It was tried to systematically analyze the results in this study from various points of view in order to consistently understand the separation mechanism in RPLC.On the basis of the results about surface diffusion, the surface-restricted molecular diffusion model was proposed for surface diffusion as a first approximation. The new model was formulated according to the absolute rate theory. This model is effective for a comprehensive interpretation of the intrinsic characteristics and mechanism of surface diffusion.New moment equations were derived for monolithic columns packed with continuous porous separation media by solving the basic equations of the general rate model of chromatography in the Laplace domain. They correlate the peak moments and some parameters characterizing the retention equilibrium and the mass transfer kinetics in monolithic columns. Some items of new information on the mass transfer kinetics in C_<18>-silica monolithic columns were derived by applying the new moment equations to a set of experimental data. The validity of the new moment equations was confirmed. Less
在反相液相色谱(RPLC)条件下,采用脉冲响应实验和矩分析法对柱内传质现象进行了动力学研究。采用了不同物理化学性质的固定相,即键合不同碳数烷基链的多孔硅胶颗粒、键合<18>不同表面覆盖度C-配体的多孔硅胶颗粒、键合苯基的多孔硅胶颗粒、苯乙烯-二乙烯苯共聚物的多孔硅胶颗粒和石墨碳的多孔硅胶颗粒。主要以甲醇/水混合物为移动的流动相,以苯衍生物和苯酚衍生物为标准物质。通过对洗脱峰的一阶绝对矩和二阶中心矩的分析,得到了有关保留平衡和传质动力学的信息。特别是, ...更多信息 详细研究了表面扩散的动力学和机理。据作者所知,目前还没有对表面扩散进行系统的研究。从不同温度条件下的脉冲响应实验结果推导出保留平衡和表面扩散的热力学性质。为了更好地理解反相液相色谱分离机理,从不同角度对实验结果进行了系统分析,并在表面扩散研究结果的基础上,提出了表面限制性分子扩散模型作为表面扩散的一级近似。新模型是根据绝对速率理论建立的。该模型可以有效地全面解释表面扩散的内在特征和机理,通过在拉普拉斯域求解色谱通用速率模型的基本方程,推导出填充连续多孔分离介质的整体柱的新矩方程。它们关联了峰矩和表征整体柱中保留平衡和传质动力学的一些参数。将<18>新的矩方程应用于一组实验数据,得到了一些关于C_ -硅胶整体柱传质动力学的新信息。验证了新力矩方程的正确性。少
项目成果
期刊论文数量(26)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Miyabe, K., Cavazzini, A., Gritti, F., Kele, M., Guiochon, G.: "Moment Analysis of Mass Transfer Kinetics in C_<18>-Silica Monolithic Columns."Anal.Chem.. 75. 6975-6986 (2003)
Miyabe, K.、Cavazzini, A.、Gritti, F.、Kele, M.、Guiochon, G.:“C_<18>-二氧化硅整体柱中传质动力学的矩分析”。Anal.Chem.. 75。
- DOI:
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- 影响因子:0
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- 通讯作者:
Miyabe, K.: "Chromatographic Behavior of Alkyl Ligands Bonded Silica Gels"Anal. Sci.. (印刷中).
Miyabe, K.:“烷基配体键合硅胶的色谱行为”科学(正在出版)。
- DOI:
- 发表时间:
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- 影响因子:0
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- 通讯作者:
Miyabe, K.Cavazzini, A., Gritti, F., Kele, M., Guiochon, G.: "Moment Analysis of Mass Transfer Kinetics in C_<18>-Silica Monolithic Columns."Anal.Chem.. 75. 6975-6986 (2003)
Miyabe, K.Cavazzini, A.、Gritti, F.、Kele, M.、Guiochon, G.:“C_<18>-二氧化硅整体柱中传质动力学的矩分析。”Anal.Chem.. 75. 6975
- DOI:
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- 影响因子:0
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Miyabe, K.: "Analysis of the Surface Diffusion of Alkylbenzenes and p-Alkylphenols in Reversed-Phase Liquid Chromatography Using the Surface-Restricted Molecular Diffusion Model"Anal. Chem.. 73. 3096-3106 (2001)
Miyabe, K.:“使用表面限制分子扩散模型分析反相液相色谱中烷基苯和对烷基酚的表面扩散”。
- DOI:
- 发表时间:
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- 影响因子:0
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- 通讯作者:
Miyabe, K.: "Retention and Mass Transfer Characteristics in Reversed-Phase Liquid Chromatography Using a Tetrahydrofuran-Water Solution as the Mobile Phase"J. Chromatogr. A. 919. 231-244 (2001)
Miyabe, K.:“使用四氢呋喃-水溶液作为流动相的反相液相色谱中的保留和传质特性”J。
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MIYABE Kanji其他文献
カーボンナノチューブ薄膜トランジスタのモデル化とその集積回路設計への適応
碳纳米管薄膜晶体管建模及其在集成电路设计中的应用
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
MIYABE Kanji;SUZUKI Nozomu;鹿嶋大雅,松浦智紀,廣谷潤,岸本茂,大野雄高 - 通讯作者:
鹿嶋大雅,松浦智紀,廣谷潤,岸本茂,大野雄高
Moment Analysis of Mass Transfer Kinetics in Micellar Electrokinetic Chromatography Systems
胶束电动色谱系统中传质动力学的矩分析
- DOI:
10.2116/analsci.34.215 - 发表时间:
2018 - 期刊:
- 影响因子:1.6
- 作者:
MIYABE Kanji;SUZUKI Nozomu - 通讯作者:
SUZUKI Nozomu
Modeling of carbon nanotube thin film transistors and its application for circuit design including characteristic variations
碳纳米管薄膜晶体管的建模及其在电路设计(包括特性变化)中的应用
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
MIYABE Kanji;SUZUKI Nozomu;鹿嶋大雅,松浦智紀,廣谷潤,岸本茂,大野雄高;鹿嶋大雅,松浦智紀,廣谷潤,岸本茂,大野雄高 - 通讯作者:
鹿嶋大雅,松浦智紀,廣谷潤,岸本茂,大野雄高
MIYABE Kanji的其他文献
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{{ truncateString('MIYABE Kanji', 18)}}的其他基金
Development of analytical method for kinetic study on intermolecular interactions and solute permeation at the interface of molecular aggregates
分子聚集体界面分子间相互作用和溶质渗透动力学研究分析方法的发展
- 批准号:
20K05570 - 财政年份:2020
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Kinetic study of intermolecular interaction by liquid chromatography
液相色谱法研究分子间相互作用的动力学
- 批准号:
24550096 - 财政年份:2012
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of New Strategy for Analysis of Chromatographic Behavior on the Basis of Moment Theory
基于矩理论的色谱行为分析新策略的开发
- 批准号:
21350040 - 财政年份:2009
- 资助金额:
$ 2.24万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
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Discovery Grants Program - Individual