权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

A Novel Method for Estimating Blood Oxygen That Aims In Situ Analysis of Retinal Metabolism - Spectrum colorimetric analysis -

一种旨在原位分析视网膜代谢的血氧估算新方法 - 光谱比色分析 -

基本信息

批准号：
12650415
负责人：
AIZU Yoshihisa
金额：
$ 2.62万
依托单位：
MURORAN INSTITUTE OF TECHNOLOGY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

The purpose of this study is to develop a method for evaluating blood oxygen, which may be applied in the near future to in situ measurements of retinal metabolism. Some topical results are briefly reviewed below.1. To measure spectral reflectances above a blood vessel and on the surrounding tissue simultaneously, a measuring apparatus was constructed by using a dual-type multi-channel spectrometer and computer.2. A new method was proposed for analysis of spectral reflectances in terms of the dominant wavelength and the excitation purity in the CIEXYZ colorimetric system. According to this method, the analyzing software was developed and successfully used for discriminating between vein and artery.3. By producing spectral reflectance data with various conditions by using the Monte Carlo method, a derivation of oxygen saturation from the dominant wavelength was tried. The result gives rough estimation of the saturation but its quality was not enough.4. To estimate an absolute value of the saturation, a different approach was investigated by using the multiple regression analysis combined with the Monte Carlo simulation. The result improved the estimation.5. The usefulness of this method was verified by experiments with phantom models consisting of the Intralipid solution, pigments and blood. Erroneous estimation was made in case of spectra having noises.6. To apply the proposed method to retinal oxymetry, a method using a reference table that gives directly the oxygen saturation from spectra was newly introduced. The software which follows this method was developed.7. To verify the feasibility of this method, experiments were conducted for samples with known parameters. Measured reflectance spectra were successfully used to estimate the oxygen saturation by using the present method. Measurements with weak light-intensity still suffer from significant errors, but in usual cases results are acceptable.

本研究的目的是开发一种用于评估血氧的方法，该方法可能在不久的将来应用于视网膜代谢的原位测量。下面简要回顾了一些专题结果。为了同时测量血管上方和周围组织的光谱反射率，利用双通道光谱仪和计算机构建了测量装置.提出了一种根据CIEXYZ色度系统的主波长和激发纯度分析光谱反射率的新方法。根据该方法，开发了分析软件，并成功应用于静脉和动脉的识别.通过使用Monte Carlo方法在各种条件下产生光谱反射率数据，尝试从主波长导出氧饱和度。结果给出了饱和度的粗略估计，但其质量不够.为了估计饱和度的绝对值，通过使用与Monte Carlo模拟相结合的多元回归分析来研究不同的方法。结果改进了估计.该方法的有效性通过实验验证与体模模型组成的Intraperoid溶液，色素和血液。在光谱有噪声的情况下，估计错误.为了将所提出的方法应用于视网膜血氧定量，新引入了一种使用参考表的方法，该参考表直接从光谱给出氧饱和度。开发了基于该方法的软件.为了验证该方法的可行性，对已知参数的样品进行了实验。测量的反射光谱被成功地用于估计血氧饱和度，通过使用本方法。弱光强度的测量仍然会有很大的误差，但在通常情况下，结果是可以接受的。