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Hybrid Spectroscopic Topography for Functional Imaging of Oxygenation

用于氧合功能成像的混合光谱形貌

基本信息

批准号：
18560404
负责人：
AIZU Yoshihisa
金额：
$ 2.59万
依托单位：
Muroran Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18560404/
关键词：
Spectral reflectance oxygen saturation skin measurement topography multiple regression analysis

项目摘要

The purpose of this study is to develop hybrid optical topography for bio-medicine, which provides us simultaneous measurements on the flow, concentration and oxygenation of blood together with the depth and thickness of the blood layer in skin tissue.1. Optical absorbance properties of blood were investigated to choose the optimum wavelength of 780 and 830 nm, the latter of which was found to better for sensitivity.2. A new method was proposed for estimation of the blood concentration including optical path length using the time-integrated absorbance of speckle images and their multiple regression analysis based on the modified Lambert-Beer law.3. An apparatus for speckle image acquisition and image processing program were developed and optimized, and used to make experiments using skin tissue phantoms based on the agar solution. The result confirmed the usefulness for dig the relative variation.4. Deconvolution processing was developed on the basis of Gaussian point spread function to sharpen topographic images.5. Analyzing algorithm and program were developed by using our own method with isosbestic wavelengths to estimate the hemoglobin concentration (mol/liter) and oxygenation (%), together with the depth and thickness under certain conditions.6. The proposed method was finally unified with the preceding technique to develop a system for measuring the depth and thickness as well as the blood flow and concentration and oxygen saturation. The system was applied to experiments on skin tissue phantoms and human volunteers to verify the usefulness including resolution.

本研究的目的是开发用于生物医学的混合光学形貌术，其为我们提供血液的流量、浓度和氧合以及皮肤组织中血液层的深度和厚度的同时测量。研究了血液的吸光特性，选择了780和830 nm的最佳波长，发现后者的灵敏度更好。2.基于修正的朗伯-比尔定律，提出了一种利用散斑图像的时间积分吸光度及其多元回归分析来估计包括光程长度在内的血药浓度的新方法.研制并优化了散斑图像采集装置和图像处理程序，并利用琼脂溶液为基质的皮肤组织模型进行了实验。结果证实了挖掘相对变异的有效性.基于高斯点扩散函数进行反卷积处理，对地形图像进行锐化.利用等吸光波长法，开发了分析算法和程序，在一定条件下估算了血红蛋白浓度（mol/L）和氧合度（%），以及深度和厚度.最后，将该方法与上述技术相结合，开发出一种用于测量深度和厚度以及血液流量和浓度以及血氧饱和度的系统。该系统被应用于皮肤组织模型和人体志愿者的实验，以验证包括分辨率的有用性。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Motion imaging of objects in layers hidden by scattering media using low-coherence speckle interferometry

使用低相干散斑干涉测量法对被散射介质隐藏的层中的物体进行运动成像

DOI：
发表时间：
2008
期刊：
Optics & LaserTechnology 40
影响因子：
0
作者：
井上貴裕;七戸希;井上貴裕;佐野勇人;N. Nanato;N. Nanato;佐野勇人;N. Nanato;N. Nanatc;井上貴裕;七戸希;井上貴裕;竹内和哉;Naomichi Yokoi and Yoshihisa Aizu
通讯作者：
Naomichi Yokoi and Yoshihisa Aizu

近赤外バイオスペックルを利用した分光血流イメージング

使用近红外生物斑点的光谱血流成像