Protein-Hydroxyapatite Hybrid Coating on Titatium Substrate by the Sol-Gel Process

通过溶胶-凝胶法在钛基底上形成蛋白质-羟基磷灰石杂化涂层

• 批准号: 12650706
• 负责人: HIRAI Shinji
• 金额: $ 2.3万
• 依托单位: Muroran Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12650706/
• 关键词: Hybrid Coating; Sol-Gel Process; Collagen; Silk Fibroin; Amorphous Hydroxyapatite; Polyvinilpyrrolidone; UV Irradiation; Titanium; チタン; ゾル-ゲル法; 絹フィブロイン; 細胞付着試験; 擬似体液浸漬; ゾルーゲル法; 絹; 水酸アパタイト; チタン基板; 細胞活性; 疑似体液浸漬実験

To improve the bone formation, the hybrid coating in which the collagen or silk fibroin dispersed in the organically modified amorphous hydroxyapatite using polyvinilpyrrolidone were prepared by a sol-gel process combined with UV irradiation at ambient temperature after dipping /withdrawing a substrate into/from the sol. When the coating was modified by polyvinilpyrrolidone, the elastic modulus of coating increased with increasing its content, and an adhesion of coating was consequently improved. SEM observation indicated that some crystallites of hydroxyapatite were deposited after slight three days of immersion in simulated body fluid, whereas no change was observed on the surface of titanium substrate and original hydroxyapatite coating.

为了改善骨形成，在将基材浸入溶胶中/从溶胶中取出后，通过溶胶-凝胶工艺结合环境温度下的紫外线照射来制备混合涂层，其中使用聚乙烯吡咯烷酮将胶原蛋白或丝素蛋白分散在有机改性的无定形羟基磷灰石中。当聚乙烯吡咯烷酮对涂层进行改性时，随着其含量的增加，涂层的弹性模量增大，从而提高了涂层的附着力。 SEM观察表明，在模拟体液中浸泡3天后，有一些羟基磷灰石微晶沉积出来，而钛基体和原始羟基磷灰石涂层表面没有观察到任何变化。

项目成果

K.Watanabe,M.Sakairi,H.Takahashi,K.Takahiro,S.Nagata and S.Hirai: "Formation of Composite Oxide Films on Aluminum by Sol-Gel Coating and Anodizing-For the Development of High Performance Aluminum Electrolytic Capacitors-"J.Electochem.Soc.. (掲載決定).

K. Watanabe、M. Sakairi、H. Takahashi、K. Takahiro、S. Nagata 和 S. Hirai：“通过溶胶凝胶涂层和阳极氧化在铝上形成复合氧化膜 - 用于高性能铝电解电容器的开发 - “J.Electochem.Soc..（已决定出版）。

K. Watanabe, M. Sakairi, H. Takahashi, K. Takahiro, S. Nagata, S. Hirai: "Anodizing of Aluminum Coated with Silicon Oxide by Sol-Gel Coating"J. Electrochemical. Soc.. 148-11. B473-B481 (2001)

K. Watanabe，M. Sakairi，H. Takahashi，K. Takahiro，S. Nagata，S. Hirai：“通过溶胶-凝胶涂层对涂覆有二氧化硅的铝进行阳极氧化”J。

K.Watanabe, M.Sakairi, H.Takahashi, S.Nagata and S.Hirai: "Anodizing of Aluminum Covered with SiO2 by Sol-Gel Coating-Formation Mechanism of Composite Oxide Films with High Potential Sustainability"Proceedings of The ECS & ISE Joint International Meeting.

K.Watanabe、M.Sakairi、H.Takahashi、S.Nagata 和 S.Hirai：“溶胶-凝胶涂层法对 SiO2 覆盖的铝进行阳极氧化——具有高潜力可持续性的复合氧化物薄膜的形成机制”ECS 论文集

K.Watanabe, M.Sakairi, H.Takahashi, K.Takahiro, S.Nagata, S.Hirai: "Anodizing of Aluminum Coated with Silicon Oxide by a Sol-Gel coating"J. Electrochemical Soc.. 148・11. B473-B481 (2001)

K.Watanabe、M.Sakairi、H.Takahashi、K.Takahiro、S.Nagata、S.Hirai：“通过溶胶-凝胶涂层对涂覆有二氧化硅的铝进行阳极氧化” J. Electrochemical Soc.. 148・11。 -B481 (2001)

平井伸治, 嶋影和宜, 近藤幹夫, 金井富義, 和田健二: "ゾル-ゲル法によるアルミニウムへの耐化学性および親水性被覆"日本金属学会誌. 64・3. 195-201 (2001)

Shinji Hirai、Kazuyoshi Shimakage、Mikio Kondo、Tomiyoshi Kanai、Kenji Wada：“利用溶胶-凝胶法的铝的耐化学性和亲水性涂层”日本金属学会杂志 64・3（2001）。