SYNTHESIS OF β-SHEET-TERMINATER WITH A VIEW TO DEVELOPING MEDICAL THERAPY FOR ALZHEIMER'S DISEASE

β-片层终止子的合成以开发阿尔茨海默病的医学疗法

• 批准号: 12650861
• 负责人: YAMADA Norihiro
• 金额: $ 2.37万
• 依托单位: CHIBA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12650861/
• 关键词: Alzheiraer's disease; β-sheet structure; hydrogen bonding; amyloid fibril; proline; peptide; amphiphile; organogel; FT-IR; リオトリピック液晶

Amphiphilic molecules that contain a tripeptide moiety form an aggregate not only in water but also in organic solvents. The aggregate possesses fibrous morphology and involves a rich amount of parallel β-sheet structure of peptides, which is similar to a β-peptide called an amyloid fibril. These similarities suggest that the tripeptide containing amphiphiles are suitable for an amyloid model. In the present study, we attempted to disintegrate the β-sheet assemblage by addition of a terminator molecule that lacked two proton donors for the interpeptide H-bonding. Aggregation of a tripeptide-containing amphiphile is accompanied by gel formation. The organogel turned into a light solution by addition of the terminator molecule.

含有三肽部分的两亲性分子不仅在水中而且在有机溶剂中形成聚集体。聚集体具有纤维状形态，并且涉及大量的肽的平行β-折叠结构，其类似于称为淀粉样蛋白原纤维的β-肽。这些相似性表明，含有两亲物的三肽适合于淀粉样蛋白模型。在本研究中，我们试图通过添加终止剂分子来分解β-折叠组装体，该终止剂分子缺少两个用于肽间氢键的质子供体。含有三肽的两亲物的聚集伴随着凝胶形成。通过加入终止剂分子，有机凝胶变成了轻溶液。

项目成果

Norihiro Yamada: "Formation of β-Sheet Assemblage with a View to Developing an Amyloid Model"Synlett. No.5. 575-586 (2000)

Norihiro Yamada：“以开发淀粉样蛋白模型为目的的 β-片层组合的形成”Synlett No.575-586 (2000)。

Norihiro Yamada: "Specific Aggregate Structure Formation from Peptide-Containing Lipids"J. Jpn. Oil Chemists' Soc.. 49-5. 435-446 (2000)

Norihiro Yamada：“含肽脂质的特定聚集结构形成”J。

Norihiro Yamada: "Formation of β-Sheet Assemblage with a View to Developing an Amyloid Model"Synlett. No. 5. 575-586 (2000)

Norihiro Yamada：“以开发淀粉样蛋白模型为目的的 β-片层组合的形成”Synlett，No. 5. 575-586 (2000)。

山田哲弘: "ペプチド脂質の特異的構造形成"油化学. 49・5. 435-446 (2000)

Tetsuhiro Yamada：“肽脂质的特定结构形成”《石油化学》49・5（2000）。

山田 哲弘: "ペプチド脂質の特異的構造形成"油化学. 49. 435-446 (2000)

Tetsuhiro Yamada：“肽脂质的特定结构形成”《石油化学》49. 435-446 (2000)。