SYNTHESIS OF β-SHEET-TERMINATER WITH A VIEW TO DEVELOPING MEDICAL THERAPY FOR ALZHEIMER'S DISEASE

β-片层终止子的合成以开发阿尔茨海默病的医学疗法

• 批准号: 12650861
• 负责人: YAMADA Norihiro
• 金额: $ 2.37万
• 依托单位: CHIBA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12650861/
• 关键词: Alzheiraer's disease; β-sheet structure; hydrogen bonding; amyloid fibril; proline; peptide; amphiphile; organogel; FT-IR; リオトリピック液晶

Amphiphilic molecules that contain a tripeptide moiety form an aggregate not only in water but also in organic solvents. The aggregate possesses fibrous morphology and involves a rich amount of parallel β-sheet structure of peptides, which is similar to a β-peptide called an amyloid fibril. These similarities suggest that the tripeptide containing amphiphiles are suitable for an amyloid model. In the present study, we attempted to disintegrate the β-sheet assemblage by addition of a terminator molecule that lacked two proton donors for the interpeptide H-bonding. Aggregation of a tripeptide-containing amphiphile is accompanied by gel formation. The organogel turned into a light solution by addition of the terminator molecule.

含有三肽部分的两亲分子不仅在水中形成聚集体，而且在有机溶剂中也形成聚集体。聚集体具有纤维状形态，并含有丰富的平行β-Sheet多肽结构，类似于一种称为淀粉样原纤维的β-肽。这些相似之处表明，含有两亲分子的三肽适合于淀粉样蛋白模型。在本研究中，我们试图通过添加一个终止剂分子来分解β-Sheet组装，该终止剂分子缺乏两个用于肽间氢键的质子供体。含三肽的两亲分子的聚集伴随着凝胶的形成。通过添加终止剂分子，有机凝胶变成了光溶液。

项目成果

Norihiro Yamada: "Formation of β-Sheet Assemblage with a View to Developing an Amyloid Model"Synlett. No.5. 575-586 (2000)

Norihiro Yamada：“以开发淀粉样蛋白模型为目的的 β-片层组合的形成”Synlett No.575-586 (2000)。

Norihiro Yamada: "Specific Aggregate Structure Formation from Peptide-Containing Lipids"J. Jpn. Oil Chemists' Soc.. 49-5. 435-446 (2000)

Norihiro Yamada：“含肽脂质的特定聚集结构形成”J。

Norihiro Yamada: "Formation of β-Sheet Assemblage with a View to Developing an Amyloid Model"Synlett. No. 5. 575-586 (2000)

Norihiro Yamada：“以开发淀粉样蛋白模型为目的的 β-片层组合的形成”Synlett，No. 5. 575-586 (2000)。

山田哲弘: "ペプチド脂質の特異的構造形成"油化学. 49・5. 435-446 (2000)

Tetsuhiro Yamada：“肽脂质的特定结构形成”《石油化学》49・5（2000）。

山田 哲弘: "ペプチド脂質の特異的構造形成"油化学. 49. 435-446 (2000)

Tetsuhiro Yamada：“肽脂质的特定结构形成”《石油化学》49. 435-446 (2000)。