Supramolecular Film of Low Molecular Mass Molecule As Leucine-Zipped a-Sheet Assemblage

亮氨酸拉链α片组合体低分子量分子超分子膜

• 批准号: 14550831
• 负责人: YAMADA Norihiro
• 金额: $ 2.69万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14550831/
• 关键词: Supramolecular Film; Leucine Fastener; Hydrogen Bonding; β-sheet; Molding Press; Oligo-leucine; Peptide-containing Amphiphile; Flexible Film; 塑性加工; 加圧成形; ペプチド; 平行β-シート構浩; ロイシンジッパー; フィルム形成; FT-IRスペクトル; 両親媒性化合物; 多重水素結合

This work is the first report for the formation of a self-supporting elastic film without the use of macromolecular materials. We prepared the film using a peptide-containing amphiphile that possesses three or four consecutive leucinate residues. The amphiphile initially formed a b-sheet structure, which stacked by a fastener-like action between the side chains of leucine within the different β-sheets.

这项工作是首次报道在不使用高分子材料的情况下形成自支撑弹性膜。我们使用含有三到四个连续亮氨酸残基的含肽两亲分子来制备薄膜。该两亲分子最初形成b-折叠结构，在不同β-折叠内的亮氨酸侧链之间通过类似紧固件的作用堆积。

项目成果

長谷川健: "Cartesian-structure Analysis in Cast Films by Advanced Infrared Multiple-angle Incidence Resolution Spectroscopy"Anal.Chem.. (2004)

Ken Hasekawa：“通过高级红外多角度入射分辨率光谱对流延薄膜进行笛卡尔结构分析”Anal.Chem.. (2004)

長谷川健: "A Novel Approach of Cartesian-Structure Analysis in Cast Films by Advanced Infrared Multiple-Angle Incidence Resolution Spectroscopy"Anal.Chem.. 印刷中. (2004)

Ken Hasekawa：“通过高级红外多角度入射分辨率光谱分析流延薄膜的笛卡尔结构的新方法”Anal.Chem.. 已出版（2004 年）。

山田哲弘: "Self-supporting Elastic Film without Covalent Linkages As a Hierarchically Integrated β-Sheet Assemblage"Angew.Chem.Int.Ed.Engl.. 42(44). 5496-5499 (2003)

Tetsuhiro Yamada：“作为分层集成的 β-片组合的无共价键的自支撑弹性薄膜”Angew.Chem.Int.Ed.Engl.. 42(44) (2003)。

中嶋直敏: "超分子科学"化学同人. 496 (2004)

中岛直俊：《超分子科学》化学同人志 496 (2004)。

山田哲弘: "Self-Supporting Elastic Film without Covalent Linkages As a Hierarchically Integrated β-Sheet Assemblage"Angew.Chem.Int.Ed.Engl.. 42. 5496-5499 (2003)

Tetsuhiro Yamada：“作为分层集成的 β-片组合的无共价键的自支撑弹性薄膜”Angew.Chem.Int.Ed.Engl.. 42. 5496-5499 (2003)