Research into Formation and Structure of Helical Superstructure formed from Synthetic Bilayer Membrane

合成双层膜螺旋超结构的形成与结构研究

• 批准号: 01550687
• 负责人: YAMADA Norihiro
• 金额: $ 1.02万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01550687/
• 关键词: Synthetic Bilayer Membrane; Helical Superstructure; Amphiphile; Even-Odd-Chain Effect; Chirality; Fourier Transform Infrared Spectrum; Aggregation Morphology; Hydrogen Bond; 二分子膜; ヘリックス; 光学顕微鏡; 可視・紫外分光; 偶奇効果; 疎水鎖

Bilayer aggregate which formed from amphiphilic compound in water sometimes transforms into helical superstructure by incubation at temperatures below the gel to liquid-crystal phase transition (Tc). We investigated the helical superstructure by using more than 20 amphiphiles to elucidate driving force of the helix-formation and molecular orientation or packing structure in the helices, and obtained following results.1. Chiral, double-chain ammonium amphiphiles possessing shorter hydrophobic chain formed the helical superstructures in preference to those possessing longer hydrophobic chain; dodecyl > tridecyl > tetradecyl > pentadecyl > hexadecyl.2. Although the formation of the helical aggregates were observed in aqueous solution of an achiral, single-chain ammonium amphiphile which contained a hydrogen bonding group, the helical superstructure was predominantly formed from chiral amphiphiles rather than achiral amphiphiles. The result means that the helix-formation is promoted by the presence of an asymmetric carbon and hydrogen bonding groups. And these structural moieties cooperatively act on the helix-formation.3. Annealing was more effective to form the helical superstructure than incubation at a constant temperature below Tc.4. Electronic and infrared spectra of the amphiphiles were not changed without respect to whether the amphiphiles formed large helices or fragmental helices. Thus the molecular orientation and packing is locally identical between large and small helices.5. Electronic and infrared spectra of aqueous bilayer membranes were alternatively changed with number of carbon atoms in the hydrophobic chain, which was independent of the helix-formation. Therefore, it became apparent that the even-odd-chain effect was an general phenomenon in the bilayer systems.

由水中的两亲化合物形成的双层骨料有时会通过在凝胶以下的温度下孵育到液晶相变到液晶相变（TC）而转化为螺旋超结构。我们通过使用超过20座的两桥来阐明螺旋形成和螺旋中的分子取向或填料结构的驱动力，研究了螺旋上层结构，并在结果后获得。1。具有较短疏水性链的手性，双链两亲铵，构成了螺旋超结构，而不是具有较长疏水链的人。十二烷基> tridecyl>四烷基>五烷基>六烷基。2。尽管在含有氢键基团的精神，单链两亲物的水溶液中观察到了螺旋聚集体的形成，但螺旋超结构主要是由手性重果而不是幼稚的放大式的。结果意味着螺旋形成是通过不对称碳和氢键组的存在来促进的。这些结构部分协同作用于螺旋形成3。退火比在TC.4以下的恒定温度下孵育更有效地形成螺旋上层结构。如果不尊重两亲物是形成大螺旋或碎片螺旋的，两亲物的电子和红外光谱不会改变。因此，分子方向和填料在大型和小螺旋之间在局部相同。5。疏水链中的碳原子数量变化，疏水链中的碳原子数量替代，该光谱与螺旋形成无关。因此，很明显，均匀的链效应是双层系统中的一般现象。

项目成果

Norihiro Yamada: "Alternation of Absorption Maxima in Helical Superstructures of Chiral,Singleーchain Ammonium Amphiphiles" J.Chem.Soc.,Chem.Commun.568-569 (1990)

Norihiro Yamada：“手性单链铵两亲物螺旋超结构中吸收最大值的交替”J.Chem.Soc.，Chem.Commun.568-569 (1990)

Norihiro Yamada: "Alternation of Absorption Maxima in Helical Superstructures of Chiral,Single-chain Ammonium Amphiphiles" Journal of The Chemical Society,Chemical Communications(J.Chem.Soc.,Chem.Commun.). (1990)

Norihiro Yamada：“手性单链铵两亲物螺旋超结构中吸收最大值的交替”化学会杂志，化学通讯（J.Chem.Soc.，Chem.Commun.）。

Norihiro Yamada: "Alternation of Absorption Maxima in Helical Superstructures of Chiral, Single-chain Ammonium Amphiphiles" J. Chem. Soc., Chem. Commun.No. 7. 568-569. (1990)

Norihiro Yamada：“手性单链铵两亲物螺旋超结构中吸收最大值的交替”J. Chem。