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The reorganization of primary motor cortex with rehabilitative interventions after experimental strokes in monkeys

猴子实验性中风后通过康复干预对初级运动皮层进行重组

基本信息

批准号：
12832004
负责人：
KASAHARA Satoshi
金额：
$ 2.24万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12832004/
关键词：
primary motor cortex rehabilitative training experimental strokes reorganization compensatory movement

项目摘要

It is reported that rehabilitative intervention improves the functional outcome of patients after strokes. However, it is still unclear how it assists recovery from hemi-or monoparesis. In order to address this question, we examined voluntary movements of impaired forelimbs during recovery after experimental strokes in monkeys.(1) The forelimb movements to retrieve food pellets were analyzed with videotape recording (VTR). To take food pellets in a shallow well, intact monkeys used thumb adduction toward the first finger, while he flexed the first and the second fingers for the deep well.(2) Under Pentobarbital Na anesthesia, we examined somatotopy of the primary motor cortex of the dominant hemisphere by applying intracortical microstimulation. Representation of forelimb was almost similar to the previous reports. The distal forelimb representation (digit, wrist/forearm) was bounded medially. Movements of proximal areas (elbow and shoulder) are represented laterally. A small infarction was made by coagulating blood vessels in the area of the distal forelimb.(3) Recovery process from experimental stroke was evaluated by measuring the time required for taking pellets (Hand Performance Test : HPT) and VTR until 1 month after stroke.Monkeys could not use their impaired hands during the first 2 days. The failure to retrieve food pellets and compensatory movements such as changing posture and involvement of other joints were often observed during the first week. The time for retrieving pellets was prolonged than that before the lesion until the first month. After that, they no longer showed motor deficit in the performance test. This animal model for studying functional recovery after experimental stroke is useful for the evaluation of motor deficit. With this model, we will be able to examine further how the recovery process and reorganization in the brain are taken place.

据报道，康复干预可改善中风后患者的功能结果。然而，目前尚不清楚它如何帮助偏瘫或单侧轻瘫恢复。为了解决这个问题，我们检查了猴子实验性中风后恢复过程中受损前肢的随意运动。（1）通过录像（VTR）分析了取回食物颗粒的前肢运动。为了在浅井中取出食物颗粒，完整的猴子将拇指内收向食指，同时弯曲第一和第二手指以进入深井。（2）在戊巴比妥钠麻醉下，我们通过应用皮质内微刺激来检查优势半球初级运动皮层的躯体结构。前肢的表现几乎与之前的报告相似。远端前肢表征（手指、手腕/前臂）向内侧界定。近端区域（肘部和肩部）的运动以横向表示。通过凝固前肢远端区域的血管造成小梗塞。(3)通过测量中风后1个月服用颗粒所需的时间(手性能测试：HPT)和VTR来评估实验性中风的恢复过程。猴子在最初的2天内不能使用受损的手。在第一周，经常观察到无法收回食物颗粒和补偿性运动，例如改变姿势和涉及其他关节。取丸时间比病变前延长至第1个月。此后，他们在性能测试中不再表现出运动缺陷。这种用于研究实验性中风后功能恢复的动物模型可用于评估运动缺陷。通过这个模型，我们将能够进一步研究大脑的恢复过程和重组是如何发生的。